FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2902093670> ?p ?o ?g. }

• W2902093670 abstract "Neutrophils are a vital component of immune protection, yet in cancer they may promote tumour progression, partly by generating reactive oxygen species (ROS) that disrupts lymphocyte functions. Metabolically, neutrophils are often discounted as purely glycolytic. Here we show that immature, c-Kit+ neutrophils subsets can engage in oxidative mitochondrial metabolism. With limited glucose supply, oxidative neutrophils use mitochondrial fatty acid oxidation to support NADPH oxidase-dependent ROS production. In 4T1 tumour-bearing mice, mitochondrial fitness is enhanced in splenic neutrophils and is driven by c-Kit signalling. Concordantly, tumour-elicited oxidative neutrophils are able to maintain ROS production and T cell suppression when glucose utilisation is restricted. Consistent with these findings, peripheral blood neutrophils from patients with cancer also display increased immaturity, mitochondrial content and oxidative phosphorylation. Together, our data suggest that the glucose-restricted tumour microenvironment induces metabolically adapted, oxidative neutrophils to maintain local immune suppression." @default.
• W2902093670 created "2018-12-11" @default.
• W2902093670 creator A5004928669 @default.
• W2902093670 creator A5012865481 @default.
• W2902093670 creator A5016552816 @default.
• W2902093670 creator A5017226392 @default.
• W2902093670 creator A5021394893 @default.
• W2902093670 creator A5026518053 @default.
• W2902093670 creator A5028772864 @default.
• W2902093670 creator A5035694388 @default.
• W2902093670 creator A5039261944 @default.
• W2902093670 creator A5045660547 @default.
• W2902093670 creator A5068577073 @default.
• W2902093670 creator A5076604315 @default.
• W2902093670 creator A5080924706 @default.
• W2902093670 creator A5086290367 @default.
• W2902093670 date "2018-11-30" @default.
• W2902093670 modified "2023-10-14" @default.
• W2902093670 title "Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression" @default.
• W2902093670 cites W1486740674 @default.
• W2902093670 cites W1517175596 @default.
• W2902093670 cites W1552212814 @default.
• W2902093670 cites W1580678794 @default.
• W2902093670 cites W1904885158 @default.
• W2902093670 cites W1906260222 @default.
• W2902093670 cites W1927075449 @default.
• W2902093670 cites W1969427270 @default.
• W2902093670 cites W1972274031 @default.
• W2902093670 cites W1973511155 @default.
• W2902093670 cites W1975827622 @default.
• W2902093670 cites W1976965953 @default.
• W2902093670 cites W1988887928 @default.
• W2902093670 cites W1989111278 @default.
• W2902093670 cites W1989647975 @default.
• W2902093670 cites W1997475495 @default.
• W2902093670 cites W2000289931 @default.
• W2902093670 cites W2000725338 @default.
• W2902093670 cites W2001174010 @default.
• W2902093670 cites W2012645913 @default.
• W2902093670 cites W2015415347 @default.
• W2902093670 cites W2033758983 @default.
• W2902093670 cites W2044640065 @default.
• W2902093670 cites W2049934590 @default.
• W2902093670 cites W2075633952 @default.
• W2902093670 cites W2076068373 @default.
• W2902093670 cites W2076881902 @default.
• W2902093670 cites W2077061494 @default.
• W2902093670 cites W2084991494 @default.
• W2902093670 cites W2088067478 @default.
• W2902093670 cites W2091506384 @default.
• W2902093670 cites W2093361250 @default.
• W2902093670 cites W2097637096 @default.
• W2902093670 cites W2100039832 @default.
• W2902093670 cites W2110271242 @default.
• W2902093670 cites W2112530582 @default.
• W2902093670 cites W2112909901 @default.
• W2902093670 cites W2132132140 @default.
• W2902093670 cites W2134294998 @default.
• W2902093670 cites W2134401635 @default.
• W2902093670 cites W2140368744 @default.
• W2902093670 cites W2146875866 @default.
• W2902093670 cites W2147286476 @default.
• W2902093670 cites W2152865860 @default.
• W2902093670 cites W2157096396 @default.
• W2902093670 cites W2163581770 @default.
• W2902093670 cites W2170164215 @default.
• W2902093670 cites W2208851958 @default.
• W2902093670 cites W2261479737 @default.
• W2902093670 cites W2276764162 @default.
• W2902093670 cites W2337300757 @default.
• W2902093670 cites W2411767313 @default.
• W2902093670 cites W2419604885 @default.
• W2902093670 cites W2463549330 @default.
• W2902093670 cites W2522038806 @default.
• W2902093670 cites W2570947205 @default.
• W2902093670 cites W2594439935 @default.
• W2902093670 cites W2606475335 @default.
• W2902093670 cites W2767795362 @default.
• W2902093670 cites W4211253912 @default.
• W2902093670 doi "https://doi.org/10.1038/s41467-018-07505-2" @default.
• W2902093670 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6269473" @default.
• W2902093670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30504842" @default.
• W2902093670 hasPublicationYear "2018" @default.
• W2902093670 type Work @default.
• W2902093670 sameAs 2902093670 @default.
• W2902093670 citedByCount "182" @default.
• W2902093670 countsByYear W29020936702019 @default.
• W2902093670 countsByYear W29020936702020 @default.
• W2902093670 countsByYear W29020936702021 @default.
• W2902093670 countsByYear W29020936702022 @default.
• W2902093670 countsByYear W29020936702023 @default.
• W2902093670 crossrefType "journal-article" @default.
• W2902093670 hasAuthorship W2902093670A5004928669 @default.
• W2902093670 hasAuthorship W2902093670A5012865481 @default.
• W2902093670 hasAuthorship W2902093670A5016552816 @default.
• W2902093670 hasAuthorship W2902093670A5017226392 @default.
• W2902093670 hasAuthorship W2902093670A5021394893 @default.
• W2902093670 hasAuthorship W2902093670A5026518053 @default.
• W2902093670 hasAuthorship W2902093670A5028772864 @default.
• W2902093670 hasAuthorship W2902093670A5035694388 @default.

• next