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• W2902095392 abstract "Complex tissue communication networks function throughout an organism's lifespan to maintain tissue homeostasis. Using the genetic model Drosophila melanogaster, we have defined a network of immune responses activated following the induction of muscle stresses, including hypercontraction, detachment, and oxidative stress. Of these stressors, loss of genes causing muscle detachment produce the strongest levels of JAK-STAT activation. In one of these mutants, fondue (fon), we also observe hemocyte recruitment and the accumulation of melanin at muscle attachment sites (MASs), indicating a broad involvement of innate immune responses upon muscle detachment. Loss of fon results in pathogen-independent Toll signaling in the fat body and increased expression of the Toll-dependent antimicrobial peptide (AMP) Drosomycin. Interestingly, genetic interactions between fon and various Toll pathway components enhance muscle detachment. Finally, we show that JAK-STAT and Toll signaling are capable of reciprocal activation in larval tissues. We propose a model of tissue communication for the integration of immune responses at the local and systemic level in response to altered muscle physiology." @default.
• W2902095392 created "2018-12-11" @default.
• W2902095392 creator A5049828025 @default.
• W2902095392 creator A5052825116 @default.
• W2902095392 creator A5072858487 @default.
• W2902095392 creator A5079486904 @default.
• W2902095392 creator A5081184678 @default.
• W2902095392 date "2018-01-01" @default.
• W2902095392 modified "2023-10-17" @default.
• W2902095392 title "A tissue communication network coordinating innate immune response during muscle stress" @default.
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