FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2902133065> ?p ?o ?g. }

• W2902133065 endingPage "312" @default.
• W2902133065 startingPage "302" @default.
• W2902133065 abstract "The disturbance of maternal immune tolerance to a semiallogeneic fetus is recognized as one of the key pathologies of preeclampsia (PE), in which an imbalance between the inflammation-limiting regulatory T cells (Tregs) and the inflammation-mediating Th17 cells plays an essential role. Previously, we reported that the abnormal upregulation of tetraspannin CD81 in trophoblast cells (fetal component) participated in the pathogenesis of PE. However, as one of the potential immune regulatory molecules, whether CD81 induces PE by interfering with the balance of the maternal immune system has not yet been clarified. Thus, we investigated the relationship between the upregulation of CD81 in trophoblast cells and the imbalance of Treg and Th17 cells in mothers. Here, we demonstrated that upregulation of CD81 in trophoblast cells was accompanied by a decrease in Treg cells and an increase in Th17 cells in both the basal plate (placental maternal side) and peripheral blood of patients with PE. In vitro culture of naïve T cells with medium from the CD81-overexpressing trophoblast cell line HTR-8 resulted in enhanced differentiation of T cells into Th17 cells and decreased the formation of Tregs, which was dependent on the paracrine signaling of IL-6 in trophocytes, induced by CD81. In a CD81-induced PE rat model, we found a significant shift of T cell differentiation towards Th17 cells, and administration of IL-6 antibody mitigated the PE phenotype and the imbalance of the Treg/Th17 cells. These results define a vital regulatory cascade involving trophocyte-derived CD81, IL-6, and maternal Treg/Th17 cells in the pathogenesis of PE and suggests new therapeutic approaches based on CD81 and IL-6 downregulation to prevent human PE." @default.
• W2902133065 created "2018-12-11" @default.
• W2902133065 creator A5003182616 @default.
• W2902133065 creator A5005859926 @default.
• W2902133065 creator A5006012404 @default.
• W2902133065 creator A5006305337 @default.
• W2902133065 creator A5027592431 @default.
• W2902133065 creator A5030723398 @default.
• W2902133065 creator A5032544653 @default.
• W2902133065 creator A5051078713 @default.
• W2902133065 creator A5051092144 @default.
• W2902133065 creator A5062053302 @default.
• W2902133065 creator A5083093957 @default.
• W2902133065 creator A5083465771 @default.
• W2902133065 date "2018-11-28" @default.
• W2902133065 modified "2023-10-18" @default.
• W2902133065 title "Upregulation of CD81 in trophoblasts induces an imbalance of Treg/Th17 cells by promoting IL-6 expression in preeclampsia" @default.
• W2902133065 cites W1576249624 @default.
• W2902133065 cites W1600214033 @default.
• W2902133065 cites W1831694374 @default.
• W2902133065 cites W1965512756 @default.
• W2902133065 cites W1984909066 @default.
• W2902133065 cites W1993474041 @default.
• W2902133065 cites W1995272947 @default.
• W2902133065 cites W2003107797 @default.
• W2902133065 cites W2012812817 @default.
• W2902133065 cites W2020151812 @default.
• W2902133065 cites W2028195000 @default.
• W2902133065 cites W2028369131 @default.
• W2902133065 cites W2031792869 @default.
• W2902133065 cites W2035358488 @default.
• W2902133065 cites W2044960250 @default.
• W2902133065 cites W2059452586 @default.
• W2902133065 cites W2062687768 @default.
• W2902133065 cites W2092134310 @default.
• W2902133065 cites W2103600875 @default.
• W2902133065 cites W2110361388 @default.
• W2902133065 cites W2125012706 @default.
• W2902133065 cites W2138683691 @default.
• W2902133065 cites W2159472318 @default.
• W2902133065 cites W2166282414 @default.
• W2902133065 cites W2166952082 @default.
• W2902133065 cites W2168559361 @default.
• W2902133065 cites W2193736634 @default.
• W2902133065 cites W2295247670 @default.
• W2902133065 cites W2528654208 @default.
• W2902133065 cites W2532746166 @default.
• W2902133065 cites W2586389077 @default.
• W2902133065 cites W2702621018 @default.
• W2902133065 cites W2754597397 @default.
• W2902133065 cites W2781967436 @default.
• W2902133065 cites W2793633504 @default.
• W2902133065 cites W4211203631 @default.
• W2902133065 doi "https://doi.org/10.1038/s41423-018-0186-9" @default.
• W2902133065 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6318306" @default.
• W2902133065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30487550" @default.
• W2902133065 hasPublicationYear "2018" @default.
• W2902133065 type Work @default.
• W2902133065 sameAs 2902133065 @default.
• W2902133065 citedByCount "33" @default.
• W2902133065 countsByYear W29021330652020 @default.
• W2902133065 countsByYear W29021330652021 @default.
• W2902133065 countsByYear W29021330652022 @default.
• W2902133065 countsByYear W29021330652023 @default.
• W2902133065 crossrefType "journal-article" @default.
• W2902133065 hasAuthorship W2902133065A5003182616 @default.
• W2902133065 hasAuthorship W2902133065A5005859926 @default.
• W2902133065 hasAuthorship W2902133065A5006012404 @default.
• W2902133065 hasAuthorship W2902133065A5006305337 @default.
• W2902133065 hasAuthorship W2902133065A5027592431 @default.
• W2902133065 hasAuthorship W2902133065A5030723398 @default.
• W2902133065 hasAuthorship W2902133065A5032544653 @default.
• W2902133065 hasAuthorship W2902133065A5051078713 @default.
• W2902133065 hasAuthorship W2902133065A5051092144 @default.
• W2902133065 hasAuthorship W2902133065A5062053302 @default.
• W2902133065 hasAuthorship W2902133065A5083093957 @default.
• W2902133065 hasAuthorship W2902133065A5083465771 @default.
• W2902133065 hasBestOaLocation W29021330651 @default.
• W2902133065 hasConcept C104317684 @default.
• W2902133065 hasConcept C127561419 @default.
• W2902133065 hasConcept C172680121 @default.
• W2902133065 hasConcept C203014093 @default.
• W2902133065 hasConcept C2522874641 @default.
• W2902133065 hasConcept C2776408679 @default.
• W2902133065 hasConcept C2776507628 @default.
• W2902133065 hasConcept C2776914184 @default.
• W2902133065 hasConcept C2776953305 @default.
• W2902133065 hasConcept C2777218350 @default.
• W2902133065 hasConcept C2777495146 @default.
• W2902133065 hasConcept C2777702733 @default.
• W2902133065 hasConcept C2779234561 @default.
• W2902133065 hasConcept C502942594 @default.
• W2902133065 hasConcept C54355233 @default.
• W2902133065 hasConcept C55493867 @default.
• W2902133065 hasConcept C86803240 @default.
• W2902133065 hasConcept C8891405 @default.
• W2902133065 hasConcept C95444343 @default.
• W2902133065 hasConceptScore W2902133065C104317684 @default.

• next