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- W2902146323 abstract "An appropriate and precise identification of high-risk individuals to develop cardiovascular diseases (CVD) is of high importance to reduce these kinds of diseases, a major health concern worldwide. Therefore, the aim of this research was to evaluate prognostic CVD biomarkers in Mexican women exposed to inorganic arsenic via drinking water. Then, a cross-sectional study including 190 women was achieved. Urinary arsenic (UAs) levels were analyzed as exposure biomarker to that metalloid. While, plasma asymmetric dimethylarginine (ADMA), adipocyte fatty acid-binding protein (FABP4), adiponectin, and chemerin levels, hypertriglyceridemic waist (HW) phenotype, atherogenic index of plasma (AIP), and Framingham risk score (FRS) were assessed as prognostic CVD biomarkers. Mean UAs level detected in the evaluated urinary samples was 45.0 ± 40.0 μg/g creatinine. In addition, mean plasma ADMA, FABP4, chemerin and adiponectin levels were 0.68 µmol/L, 20.3 ng/mL, 12.5 μg/mL, and 255 ng/mL, correspondingly. Approximately, 54% of women participants displayed an HW phenotype. Regarding AIP and FRS values, 0.12 ± 0.15 and 7.50 ± 8.00 were found, respectively. Besides, strong and significant associations (p < 0.05) between UAs and AIP, ADMA, and FABP4 were distinguished. Also, after a multivariate analysis, the association between those variables persisted after adjustment for traditional risk factors of CVD. In conclusion, according to the results found in this research, the most sensible CVD biomarkers distinguished in this study were AIP, ADMA, and FABP4. Nevertheless, more studies are necessary to confirm the results found in this investigation." @default.
- W2902146323 created "2018-12-11" @default.
- W2902146323 creator A5004239033 @default.
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- W2902146323 creator A5062769828 @default.
- W2902146323 creator A5063611428 @default.
- W2902146323 creator A5089441377 @default.
- W2902146323 date "2019-03-01" @default.
- W2902146323 modified "2023-10-18" @default.
- W2902146323 title "Impact of arsenic exposure on clinical biomarkers indicative of cardiovascular disease risk in Mexican women" @default.
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- W2902146323 doi "https://doi.org/10.1016/j.ecoenv.2018.11.088" @default.
- W2902146323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30500737" @default.
- W2902146323 hasPublicationYear "2019" @default.
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