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• W2902165399 abstract "Detection of rare tumor cells circulating in the blood ( CTC s) presents technical challenges. CellSearch, the only approved system for clinical use, fails to capture epithelial cell adhesion molecule‐negative CTC s such as malignant pleural mesothelioma ( MPM ). We have developed a novel microfluidic device ( CTC ‐chip) in which any Ab to capture CTC s is conjugated. The CTC ‐chip was coated with an Ab against podoplanin that is abundantly expressed on MPM . Circulating tumor cell ‐detection performance was evaluated in experimental models in which MPM cells were spiked in blood sampled from a healthy volunteer and in clinical samples drawn from MPM patients. The CTC ‐chip showed superior CTC ‐detection performance over CellSearch in experimental models (sensitivity, 63.3%‐64.5% vs 0%‐1.1%; P < .001) and in clinical samples ( CTC ‐positivity, 68.8% vs 6.3%; P < .001). A receiver operating characteristic ( ROC ) analysis showed that the CTC test provided a significant diagnostic performance in discrimination of unresectable disease from resectable disease (area under the ROC curve, 0.851; P = .003). The higher CTC count (≥2 cells/mL) was significantly associated with a poor prognosis ( P = .030). The novel CTC ‐chip enabled sensitive detection of CTC s, which provided significant diagnostic and prognostic information in MPM ." @default.
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• W2902165399 date "2019-01-08" @default.
• W2902165399 modified "2023-10-09" @default.
• W2902165399 title "Detection of circulating tumor cells with a novel microfluidic system in malignant pleural mesothelioma" @default.
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• W2902165399 doi "https://doi.org/10.1111/cas.13895" @default.
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