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- W2902166885 startingPage "261" @default.
- W2902166885 abstract "Abstract Spermatozoa are specialized cells that are essentially silent in transcription and translation. However, their proteome profile changes significantly during their transit from the testis through the male reproductive tract until fertilization occurs in the ampulla of the fallopian tube. This dynamic range of proteome not only represents the abundance of expressed proteins, but also posttranslational modifications (PTMs) acquired by the male germ cells during the processes of maturation, capacitation, and hyperactivation. One of the major forms of PTMs is brought about by enhanced generation of reactive oxygen species (ROS) or by ROS themselves. At physiological ROS levels, ROS-induced PTMs, such as phosphorylation of sperm proteins, are required for their proper functioning. On the other hand, ROS pose a threat to expressed proteins by oxidatively modifying them through the process of carbonylation and rendering these proteins nonfunctional. This chapter deals with ROS-mediated alterations in the proteome profile of semen under pathophysiological condition with oxidative predominance and redox modifications on sperm proteins by ROS. The importance of such alterations/modifications is also discussed in the light of development of biomarkers for infertility evaluation and development of therapeutic strategies." @default.
- W2902166885 created "2018-12-11" @default.
- W2902166885 creator A5030772196 @default.
- W2902166885 creator A5056393996 @default.
- W2902166885 creator A5074171675 @default.
- W2902166885 date "2019-01-01" @default.
- W2902166885 modified "2023-09-26" @default.
- W2902166885 title "Oxidative Stress and Sperm Dysfunction" @default.
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