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• W2902173935 endingPage "6222" @default.
• W2902173935 startingPage "6209" @default.
• W2902173935 abstract "Abstract Aging contributes to an increased risk of developing a number of neurodegenerative and chronic disorders, predominantly related to oxidative stress (OS) and defects in the antioxidant balance. This study focused on the antisenescence effect of four plant species ( Falcaria vulgaris, Ixiolirion tataricum, Ajuga chamaecistus, and Scabiosa flavida ) on H 2 O 2 ‐induced premature senescence in rat NIH3T3 fibroblasts, which were found to be rich in effective phytochemicals with traditional ethnobotanical backgrounds. Plant materials were collected, identified, and extracted. To determine the viability of NIH3T3 cells, an MTT assay was conducted. The levels of OS markers and the senescence‐associated ß‐galactosidase (SA‐ß‐GAL) activity were analyzed by the Elisa reader. The cell cycle pattern was evaluated by flow cytometry. The expression of senescence‐related inflammatory cytokines and the molecules involved in aging signaling pathways were investigated using the real‐time reverse transcription polymerase chain reaction (RT‐PCR). H 2 O 2 treatment decreased cell viability and increased lipid peroxidation (LPO) and the reactive oxygen species (ROS) in NIH3T3s. However, S. flavida exhibited low cytotoxicity, reduced OS and SA‐ß‐GAL activities in NIH3T3 cells compared with the H 2 O 2 ‐treated group. I. tataricum was the second best plant, although it was more toxic to NIHT3T cells. S. flavida decreased G0/G1 arrest and facilitated the G2/M transition of NIH3T3s, also downregulated the expression of p3 8, p53 , p16 , and the related inflammatory mediators. S. flavida potentially modulated senescence‐associated hallmarks in fibroblasts exposed to H 2 O 2 , thus it may inhibit the aging process via controlling the OS. Therefore it is a promising candidate for future antiaging explorations." @default.
• W2902173935 created "2018-12-11" @default.
• W2902173935 creator A5025708210 @default.
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• W2902173935 date "2018-11-26" @default.
• W2902173935 modified "2023-10-18" @default.
• W2902173935 title "<b>Manipulation of molecular pathways and senescence hallmarks by natural compounds in fibroblast cells</b>" @default.
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• W2902173935 cites W1966410520 @default.
• W2902173935 cites W1976973627 @default.
• W2902173935 cites W1979696021 @default.
• W2902173935 cites W1983673827 @default.
• W2902173935 cites W1984153407 @default.
• W2902173935 cites W1985425759 @default.
• W2902173935 cites W1994429692 @default.
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• W2902173935 cites W2017403940 @default.
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• W2902173935 cites W2112471324 @default.
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• W2902173935 doi "https://doi.org/10.1002/jcb.27909" @default.
• W2902173935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30474871" @default.
• W2902173935 hasPublicationYear "2018" @default.
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