FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2902178519> ?p ?o ?g. }

• W2902178519 endingPage "250" @default.
• W2902178519 startingPage "241" @default.
• W2902178519 abstract "Background Currently no methods are available to predict the clinical outcome of individual horses with equine sarcoid (ES) disease. Objective To investigate if whole blood microRNA (miRNA) profiles can predict the long‐term development of ES tumors. Animals Five horses with regression and 5 with progression of ES lesions monitored over 5‐7 years and 5 control horses free of ES for at least 5 years. Methods For this cohort study, RNA extracted from whole blood samples from the regression, progression, and control groups was used for high throughput sequencing. Known and novel miRNAs were identified using miRDeep2 and differential expression analysis was carried out by the DESeq2 algorithm. Target gene and pathway prediction as well as enrichment and network analyses were conducted using TarBase, mirPath, and metaCore from GeneGo. Results Fourteen miRNAs were differentially expressed between regression and progression groups after accounting for the control condition: 4 miRNAs (28.6%) were upregulated and 10 miRNAs (71.4%) were downregulated with >2‐fold change. Seven of the 10 downregulated miRNAs are encoded in an miRNA cluster on equine chromosome 24, homologous to the well‐known 14q32 cluster in humans. Their target genes show enrichment for pathways involved in viral carcinogenesis. Conclusions and Clinical Importance Whole blood miRNA expression profiles are associated with long‐term ES growth in horses and warrant further validation as prognostic biomarkers in a larger study cohort. Deregulation of miRNAs on equine chromosome 24 might represent a trigger for ES development." @default.
• W2902178519 created "2018-12-11" @default.
• W2902178519 creator A5013599972 @default.
• W2902178519 creator A5029969915 @default.
• W2902178519 creator A5045807702 @default.
• W2902178519 creator A5048143205 @default.
• W2902178519 creator A5087737071 @default.
• W2902178519 date "2018-12-02" @default.
• W2902178519 modified "2023-10-02" @default.
• W2902178519 title "Differences in miRNA differential expression in whole blood between horses with sarcoid regression and progression" @default.
• W2902178519 cites W1491728704 @default.
• W2902178519 cites W1588876999 @default.
• W2902178519 cites W1609044025 @default.
• W2902178519 cites W1971622878 @default.
• W2902178519 cites W1983932066 @default.
• W2902178519 cites W198819343 @default.
• W2902178519 cites W1991732359 @default.
• W2902178519 cites W1994353875 @default.
• W2902178519 cites W1997082471 @default.
• W2902178519 cites W1997532072 @default.
• W2902178519 cites W2008945738 @default.
• W2902178519 cites W2009593134 @default.
• W2902178519 cites W2014000152 @default.
• W2902178519 cites W2021880506 @default.
• W2902178519 cites W2027873015 @default.
• W2902178519 cites W2029463176 @default.
• W2902178519 cites W2036897871 @default.
• W2902178519 cites W2040787613 @default.
• W2902178519 cites W2049435756 @default.
• W2902178519 cites W2053338365 @default.
• W2902178519 cites W2059060820 @default.
• W2902178519 cites W2060559193 @default.
• W2902178519 cites W2065892246 @default.
• W2902178519 cites W2065899119 @default.
• W2902178519 cites W2070633280 @default.
• W2902178519 cites W2077987488 @default.
• W2902178519 cites W2097233439 @default.
• W2902178519 cites W2099908272 @default.
• W2902178519 cites W2102619694 @default.
• W2902178519 cites W2104488717 @default.
• W2902178519 cites W2104607843 @default.
• W2902178519 cites W2105779457 @default.
• W2902178519 cites W2105870502 @default.
• W2902178519 cites W2106637247 @default.
• W2902178519 cites W2107770226 @default.
• W2902178519 cites W2108690141 @default.
• W2902178519 cites W2111471857 @default.
• W2902178519 cites W2112192177 @default.
• W2902178519 cites W2124841394 @default.
• W2902178519 cites W2124985265 @default.
• W2902178519 cites W2130305733 @default.
• W2902178519 cites W2132047377 @default.
• W2902178519 cites W2133658633 @default.
• W2902178519 cites W2138630787 @default.
• W2902178519 cites W2139443896 @default.
• W2902178519 cites W2139655181 @default.
• W2902178519 cites W2139749624 @default.
• W2902178519 cites W2140775205 @default.
• W2902178519 cites W2142663409 @default.
• W2902178519 cites W2142778308 @default.
• W2902178519 cites W2153898423 @default.
• W2902178519 cites W2156285191 @default.
• W2902178519 cites W2172631994 @default.
• W2902178519 cites W2321838229 @default.
• W2902178519 cites W2334275085 @default.
• W2902178519 cites W2343947150 @default.
• W2902178519 cites W2465024922 @default.
• W2902178519 cites W2471770949 @default.
• W2902178519 cites W2565506012 @default.
• W2902178519 cites W2590040802 @default.
• W2902178519 cites W2592052443 @default.
• W2902178519 cites W2776332611 @default.
• W2902178519 cites W4249793386 @default.
• W2902178519 doi "https://doi.org/10.1111/jvim.15375" @default.
• W2902178519 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6335546" @default.
• W2902178519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30506726" @default.
• W2902178519 hasPublicationYear "2018" @default.
• W2902178519 type Work @default.
• W2902178519 sameAs 2902178519 @default.
• W2902178519 citedByCount "9" @default.
• W2902178519 countsByYear W29021785192020 @default.
• W2902178519 countsByYear W29021785192021 @default.
• W2902178519 countsByYear W29021785192022 @default.
• W2902178519 crossrefType "journal-article" @default.
• W2902178519 hasAuthorship W2902178519A5013599972 @default.
• W2902178519 hasAuthorship W2902178519A5029969915 @default.
• W2902178519 hasAuthorship W2902178519A5045807702 @default.
• W2902178519 hasAuthorship W2902178519A5048143205 @default.
• W2902178519 hasAuthorship W2902178519A5087737071 @default.
• W2902178519 hasBestOaLocation W29021785191 @default.
• W2902178519 hasConcept C104317684 @default.
• W2902178519 hasConcept C121608353 @default.
• W2902178519 hasConcept C126322002 @default.
• W2902178519 hasConcept C143998085 @default.
• W2902178519 hasConcept C145059251 @default.
• W2902178519 hasConcept C150194340 @default.
• W2902178519 hasConcept C2779018089 @default.
• W2902178519 hasConcept C2779134260 @default.

• next