Matches in SemOpenAlex for { <https://semopenalex.org/work/W2902178703> ?p ?o ?g. }
- W2902178703 abstract "Significance Some peptide toxins act by stabilizing the voltage sensor domains (VSDs) of voltage-gated channels in open or closed conformations. hHv1 is a human voltage-gated proton channel and has lacked a specific inhibitor to assess its roles in physiology. We designed a phage-display library of 1 million novel peptides sharing an inhibitor cysteine knot (ICK) scaffold by combining elements of natural toxins; phagemids expressing Corza6 (C6) were selected by their capacity to bind to hHv1 protein. Two C6 peptides bind to the two VSDs in hHv1 and thereby inhibit channel operation. C6 was employed to confirm hypothesized roles for hHv1 in human sperm and white blood cells. The method should prove amenable to designer toxin identification for other voltage-gated channels." @default.
- W2902178703 created "2018-12-11" @default.
- W2902178703 creator A5011954284 @default.
- W2902178703 creator A5021498481 @default.
- W2902178703 creator A5031178522 @default.
- W2902178703 creator A5033861453 @default.
- W2902178703 creator A5034699118 @default.
- W2902178703 creator A5036250995 @default.
- W2902178703 creator A5043677711 @default.
- W2902178703 creator A5051107692 @default.
- W2902178703 creator A5068550886 @default.
- W2902178703 creator A5069310025 @default.
- W2902178703 creator A5080100847 @default.
- W2902178703 creator A5083521667 @default.
- W2902178703 creator A5091645168 @default.
- W2902178703 date "2018-11-26" @default.
- W2902178703 modified "2023-10-16" @default.
- W2902178703 title "Role of human Hv1 channels in sperm capacitation and white blood cell respiratory burst established by a designed peptide inhibitor" @default.
- W2902178703 cites W1540307815 @default.
- W2902178703 cites W1658555004 @default.
- W2902178703 cites W1965191256 @default.
- W2902178703 cites W1965522673 @default.
- W2902178703 cites W1968206606 @default.
- W2902178703 cites W1975744071 @default.
- W2902178703 cites W1977410756 @default.
- W2902178703 cites W1980866572 @default.
- W2902178703 cites W1982870856 @default.
- W2902178703 cites W1983523125 @default.
- W2902178703 cites W1985661687 @default.
- W2902178703 cites W1989605789 @default.
- W2902178703 cites W1990091466 @default.
- W2902178703 cites W1990667548 @default.
- W2902178703 cites W1991412472 @default.
- W2902178703 cites W1998093640 @default.
- W2902178703 cites W2004933597 @default.
- W2902178703 cites W2009003717 @default.
- W2902178703 cites W2018568451 @default.
- W2902178703 cites W2019998982 @default.
- W2902178703 cites W2025174361 @default.
- W2902178703 cites W2028747292 @default.
- W2902178703 cites W2029592445 @default.
- W2902178703 cites W2030717015 @default.
- W2902178703 cites W2032335134 @default.
- W2902178703 cites W2039493163 @default.
- W2902178703 cites W2042914373 @default.
- W2902178703 cites W2048185837 @default.
- W2902178703 cites W2053333531 @default.
- W2902178703 cites W2055633644 @default.
- W2902178703 cites W2055703635 @default.
- W2902178703 cites W2060108293 @default.
- W2902178703 cites W2061695857 @default.
- W2902178703 cites W2063340476 @default.
- W2902178703 cites W2069187991 @default.
- W2902178703 cites W2069188987 @default.
- W2902178703 cites W2077079040 @default.
- W2902178703 cites W2083944260 @default.
- W2902178703 cites W2088734315 @default.
- W2902178703 cites W2100092871 @default.
- W2902178703 cites W2103566186 @default.
- W2902178703 cites W2109279728 @default.
- W2902178703 cites W2111370764 @default.
- W2902178703 cites W2122467599 @default.
- W2902178703 cites W2123525933 @default.
- W2902178703 cites W2129561523 @default.
- W2902178703 cites W2132571905 @default.
- W2902178703 cites W2132856129 @default.
- W2902178703 cites W2138433870 @default.
- W2902178703 cites W2147437660 @default.
- W2902178703 cites W2149857784 @default.
- W2902178703 cites W2160498023 @default.
- W2902178703 cites W2167684488 @default.
- W2902178703 cites W2169473716 @default.
- W2902178703 cites W2170720883 @default.
- W2902178703 cites W2172140523 @default.
- W2902178703 cites W2184877100 @default.
- W2902178703 cites W2200595658 @default.
- W2902178703 cites W2430860581 @default.
- W2902178703 cites W2564259995 @default.
- W2902178703 cites W2599126941 @default.
- W2902178703 cites W2738355470 @default.
- W2902178703 doi "https://doi.org/10.1073/pnas.1816189115" @default.
- W2902178703 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6294887" @default.
- W2902178703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30478045" @default.
- W2902178703 hasPublicationYear "2018" @default.
- W2902178703 type Work @default.
- W2902178703 sameAs 2902178703 @default.
- W2902178703 citedByCount "40" @default.
- W2902178703 countsByYear W29021787032019 @default.
- W2902178703 countsByYear W29021787032020 @default.
- W2902178703 countsByYear W29021787032021 @default.
- W2902178703 countsByYear W29021787032022 @default.
- W2902178703 countsByYear W29021787032023 @default.
- W2902178703 crossrefType "journal-article" @default.
- W2902178703 hasAuthorship W2902178703A5011954284 @default.
- W2902178703 hasAuthorship W2902178703A5021498481 @default.
- W2902178703 hasAuthorship W2902178703A5031178522 @default.
- W2902178703 hasAuthorship W2902178703A5033861453 @default.
- W2902178703 hasAuthorship W2902178703A5034699118 @default.
- W2902178703 hasAuthorship W2902178703A5036250995 @default.
- W2902178703 hasAuthorship W2902178703A5043677711 @default.