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- W2902217021 abstract "Neurite outgrowth underlies the wiring of the nervous system during development and regeneration. Despite a significant body of research, the underlying cytoskeletal mechanics of growth and guidance are not fully understood, and the relative contributions of individual cytoskeletal processes to neurite growth are controversial. Here, we review the structural organization and biophysical properties of neurons to make a semi-quantitative comparison of the relative contributions of different processes to neurite growth. From this, we develop the idea that neurons are active fluids, which generate strong contractile forces in the growth cone and weaker contractile forces along the axon. As a result of subcellular gradients in forces and material properties, actin flows rapidly rearward in the growth cone periphery, and microtubules flow forward in bulk along the axon. With this framework, an integrated model of neurite outgrowth is proposed that hopefully will guide new approaches to stimulate neuronal growth." @default.
- W2902217021 created "2018-12-11" @default.
- W2902217021 creator A5058022575 @default.
- W2902217021 creator A5079059260 @default.
- W2902217021 date "2018-11-26" @default.
- W2902217021 modified "2023-10-17" @default.
- W2902217021 title "An Integrated Cytoskeletal Model of Neurite Outgrowth" @default.
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