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- W2902261306 abstract "BACKGROUND:In animals and humans black raspberries (BRBs) have chemo-preventative effects against Wnt driven colorectal cancer (CRC). While BRBs have made it into clinical trials, the exact mechanisms of BRB action remain unclear. Potentially the chemo-preventative properties are linked to their impact on the gut microbiome, as diet is known to influence the microbial diversity of the gut and plays a key role in regulating intestinal homeostasis and the aetiology of CRC.OBJECTIVE:To determine the impact of a BRB diet on themicrobial biodiversityof thewild-type and malignant mouse intestine.METHODS:Adult mice in which Wnt driven tumourigenesis could be initiated by conditional deletion of Apc in the intestinal stem cell (Lgr5CreERT2) were administered a 10% BRB diet. Total DNA from faecal pellets pre- and post-BRB exposure was used for longitudinal metataxonomic analysis of the V1 to V3 regions of the 16S rRNA gene.RESULTS:Individually BRB intervention and Apc loss alter the microbial community of the gut. In combination, the microbiome changes observed in the Apc deficient intestine are attenuated upon administration of a BRB diet.CONCLUSIONS:Our results suggest that BRB intervention may protectively regulate the gut microbiota in the healthy and malignant intestine." @default.
- W2902261306 created "2018-12-11" @default.
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- W2902261306 date "2020-03-17" @default.
- W2902261306 modified "2023-10-14" @default.
- W2902261306 title "Impact of black raspberries on the normal and malignant Apc deficient murine gut microbiome" @default.
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- W2902261306 doi "https://doi.org/10.3233/jbr-180372" @default.
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