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- W2902280638 abstract "Following an acute coronary syndrome (ACS), heightened predisposition to atherothrombotic events may persist for years. Advances in understanding the pathobiology that underlies this elevated risk furnish a mechanistic basis for devising long-term secondary prevention strategies. Recent progress in ACS pathophysiology has challenged the focus on single “vulnerable plaques” and shifted toward a more holistic consideration of the “vulnerable patient,” thus highlighting the primacy of medical therapy in secondary prevention. Despite current guideline-directed medical therapy, a consistent proportion of post-ACS patients experience recurrent atherothrombosis due to unaddressed “residual risk”: contemporary clinical trials underline the pivotal role of platelets, coagulation, cholesterol, and systemic inflammation and provide a perspective on a personalized, targeted approach. Emerging data sheds new light on heretofore unrecognized residual risk factors. This review aims to summarize evolving evidence relative to secondary prevention of atherothrombosis, with a focus on recent advances that promise to transform the management of the post-ACS patient." @default.
- W2902280638 created "2018-12-11" @default.
- W2902280638 creator A5030343009 @default.
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- W2902280638 creator A5089649399 @default.
- W2902280638 date "2018-12-01" @default.
- W2902280638 modified "2023-10-16" @default.
- W2902280638 title "Medical Therapy for Long-Term Prevention of Atherothrombosis Following an Acute Coronary Syndrome" @default.
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