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• W2902295440 abstract "The past few decades have brought enormous improvements in the cure rates of childhood acute leukemia; about 85% of all children with newly diagnosed acute lymphoblastic leukemia (ALL) and 50–60% with acute myeloid leukemia (AML) experience long-term disease control after multimodal treatments that often include intensified chemotherapy. Relapsed leukemia patients pose a challenging subset of the pediatric leukemic population due to highly resistant disease and, very often, underlying organ dysfunction, calling for development of novel therapeutic approaches and innovative strategies with the power to kill refractory leukemic cells. Advanced laboratory technologies have provided fresh insights into mechanisms of relapse and leukemic cell evolution. Newer formulations of older drugs, antibody-based therapies, and molecularly targeted agents are some of the current strategies under investigation for treatment of relapsed ALL. Whole-genome sequencing has allowed characterization of the transcriptional profile of the leukemic cell, facilitating targeted therapy and leading us one step closer to precision medicine. In this rapidly evolving “race” for better and nontoxic treatments, we find ourselves in an era of the new “CARs”—chimeric antigen receptor(s)—that are defining a role for immunotherapy in childhood cancers of which one was recently approved by US Food and Drug Administration for the treatment of patients up to age 25 years with B-cell precursor acute lymphoblastic leukemia (ALL) who are refractory or in second or later relapse." @default.
• W2902295440 created "2018-12-11" @default.
• W2902295440 creator A5034307197 @default.
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• W2902295440 date "2018-11-28" @default.
• W2902295440 modified "2023-10-12" @default.
• W2902295440 title "Chimeric Antigen Receptor T Cells for Leukemias in Children: Methods, Data, and Challenges" @default.
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• W2902295440 doi "https://doi.org/10.1007/978-3-319-54368-0_4" @default.
• W2902295440 hasPublicationYear "2018" @default.
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