FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2902303456> ?p ?o ?g. }

• W2902303456 endingPage "51" @default.
• W2902303456 startingPage "39" @default.
• W2902303456 abstract "α-Naphthoflavone (αNF) is a prototype flavone, also known as a modulator of aryl hydrocarbon receptor (AhR). In the present study, we investigated the molecular mechanisms of αNF-induced cytotoxic effects in HT22 mouse hippocampal neuronal cells. αNF induced apoptotic cell death via activation of caspase-12 and -3 and increased expression of endoplasmic reticulum (ER) stress-associated proteins, including C/EBP homologous protein (CHOP). Inhibition of ER stress by treatment with the ER stress inhibitor, salubrinal, or by CHOP siRNA transfection reduced αNF-induced cell death. αNF activated mitogen-activated protein kinases (MAPKs), such as p38, JNK, and ERK, and inhibition of MAPKs reduced αNF-induced CHOP expression and cell death. αNF also induced accumulation of reactive oxygen species (ROS) and an antioxidant, N-acetylcysteine, reduced αNF-induced MAPK phosphorylation, CHOP expression, and cell death. Furthermore, αNF activated c-Src kinase, and inhibition of c-Src by a kinase inhibitor, SU6656, or siRNA transfection reduced αNF-induced ROS accumulation, MAPK activation, CHOP expression, and cell death. Inhibition of AhR by an AhR antagonist, CH223191, and siRNA transfection of AhR and AhR nuclear translocator reduced αNF-induced AhR-responsive luciferase activity, CHOP expression, and cell death. Finally, we found that inhibition of c-Src and MAPKs reduced αNF-induced transcriptional activity of AhR. Taken together, these findings suggest that αNF induces apoptosis through ER stress via c-Src-, ROS-, MAPKs-, and AhR-dependent pathways in HT22 cells." @default.
• W2902303456 created "2018-12-11" @default.
• W2902303456 creator A5009873590 @default.
• W2902303456 creator A5012945820 @default.
• W2902303456 creator A5020315859 @default.
• W2902303456 creator A5033976871 @default.
• W2902303456 creator A5041716011 @default.
• W2902303456 creator A5047885323 @default.
• W2902303456 creator A5051395459 @default.
• W2902303456 creator A5055887198 @default.
• W2902303456 creator A5073499303 @default.
• W2902303456 creator A5073810961 @default.
• W2902303456 date "2019-03-01" @default.
• W2902303456 modified "2023-09-28" @default.
• W2902303456 title "Alpha-naphthoflavone induces apoptosis through endoplasmic reticulum stress via c-Src-, ROS-, MAPKs-, and arylhydrocarbon receptor-dependent pathways in HT22 hippocampal neuronal cells" @default.
• W2902303456 cites W1531207189 @default.
• W2902303456 cites W1780547002 @default.
• W2902303456 cites W184906826 @default.
• W2902303456 cites W1935479846 @default.
• W2902303456 cites W1968958197 @default.
• W2902303456 cites W1969500743 @default.
• W2902303456 cites W1970360822 @default.
• W2902303456 cites W1973330653 @default.
• W2902303456 cites W1979379615 @default.
• W2902303456 cites W1980162425 @default.
• W2902303456 cites W1988684678 @default.
• W2902303456 cites W1991826669 @default.
• W2902303456 cites W1993774846 @default.
• W2902303456 cites W1996613294 @default.
• W2902303456 cites W1998142996 @default.
• W2902303456 cites W2001703253 @default.
• W2902303456 cites W2005283959 @default.
• W2902303456 cites W2015684044 @default.
• W2902303456 cites W2021333182 @default.
• W2902303456 cites W2025855393 @default.
• W2902303456 cites W2025980626 @default.
• W2902303456 cites W2027727753 @default.
• W2902303456 cites W2038761205 @default.
• W2902303456 cites W2039414250 @default.
• W2902303456 cites W2043387126 @default.
• W2902303456 cites W2049213482 @default.
• W2902303456 cites W2053718638 @default.
• W2902303456 cites W2054179376 @default.
• W2902303456 cites W2054562330 @default.
• W2902303456 cites W2057458129 @default.
• W2902303456 cites W2058535289 @default.
• W2902303456 cites W2062562496 @default.
• W2902303456 cites W2075584081 @default.
• W2902303456 cites W2079472464 @default.
• W2902303456 cites W2083344033 @default.
• W2902303456 cites W2085042732 @default.
• W2902303456 cites W2093853598 @default.
• W2902303456 cites W2097144774 @default.
• W2902303456 cites W2100347985 @default.
• W2902303456 cites W2107601804 @default.
• W2902303456 cites W2122768285 @default.
• W2902303456 cites W2122839221 @default.
• W2902303456 cites W2127617321 @default.
• W2902303456 cites W2140487984 @default.
• W2902303456 cites W2144481052 @default.
• W2902303456 cites W2147140209 @default.
• W2902303456 cites W2156319617 @default.
• W2902303456 cites W2285431144 @default.
• W2902303456 cites W2464101707 @default.
• W2902303456 cites W2528948513 @default.
• W2902303456 cites W2578128645 @default.
• W2902303456 cites W2665656153 @default.
• W2902303456 cites W2777375087 @default.
• W2902303456 cites W4297752584 @default.
• W2902303456 doi "https://doi.org/10.1016/j.neuro.2018.11.011" @default.
• W2902303456 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30508555" @default.
• W2902303456 hasPublicationYear "2019" @default.
• W2902303456 type Work @default.
• W2902303456 sameAs 2902303456 @default.
• W2902303456 citedByCount "8" @default.
• W2902303456 countsByYear W29023034562019 @default.
• W2902303456 countsByYear W29023034562020 @default.
• W2902303456 countsByYear W29023034562021 @default.
• W2902303456 countsByYear W29023034562022 @default.
• W2902303456 crossrefType "journal-article" @default.
• W2902303456 hasAuthorship W2902303456A5009873590 @default.
• W2902303456 hasAuthorship W2902303456A5012945820 @default.
• W2902303456 hasAuthorship W2902303456A5020315859 @default.
• W2902303456 hasAuthorship W2902303456A5033976871 @default.
• W2902303456 hasAuthorship W2902303456A5041716011 @default.
• W2902303456 hasAuthorship W2902303456A5047885323 @default.
• W2902303456 hasAuthorship W2902303456A5051395459 @default.
• W2902303456 hasAuthorship W2902303456A5055887198 @default.
• W2902303456 hasAuthorship W2902303456A5073499303 @default.
• W2902303456 hasAuthorship W2902303456A5073810961 @default.
• W2902303456 hasConcept C104317684 @default.
• W2902303456 hasConcept C139447449 @default.
• W2902303456 hasConcept C158617107 @default.
• W2902303456 hasConcept C184235292 @default.
• W2902303456 hasConcept C185592680 @default.
• W2902303456 hasConcept C190283241 @default.
• W2902303456 hasConcept C2779725641 @default.
• W2902303456 hasConcept C31573885 @default.

• next