FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2902322013> ?p ?o ?g. }

• W2902322013 endingPage "346" @default.
• W2902322013 startingPage "336" @default.
• W2902322013 abstract "Serotonin (5-hydroxytrytamine (5-HT)) plays an important role in experimental seizures. Recently, we reported the depletion of 5-HT by parachlorophynylalanine (PCPA) in whole brain to enhance 6-Hz psychomotor seizures in mice. In the present work, we investigated the effect of 5-HT depletion in cortex and hippocampus, brain regions relevant for epilepsy, on behavioral and ultra-structural changes following 6-Hz psychomotor seizures in mice. In addition, we studied the effect of sodium valproate (SVP) on behavioral, biochemical, and ultra-structural effects induced by 6 Hz. Behavioral changes induced by 6 Hz stimulation were characterized as the increased duration of Straub’s tail, stun position, twitching of vibrissae, forelimb clonus, and increased rearing and grooming. PCPA administration further enhanced while SVP reduced these behaviors in mice. The 6-Hz psychomotor seizure induced ultra-structural changes in both cortex and hippocampus in mice treated with PCPA. Furthermore, PCPA administrations followed by 6Hz-induced seizures were accompanied by reduced hippocampal and cortical 5-HT. SVP attenuated the PCPA-induced ultra-structural changes and alterations of 5-HT content in the mouse brain. The study suggests the involvement of 5-HT in the 6 Hz psychomotor seizures and in the mechanisms of action of SVP against such seizures in mice." @default.
• W2902322013 created "2018-12-11" @default.
• W2902322013 creator A5010126598 @default.
• W2902322013 creator A5018215309 @default.
• W2902322013 creator A5019144480 @default.
• W2902322013 date "2018-11-25" @default.
• W2902322013 modified "2023-09-27" @default.
• W2902322013 title "Serotonergic mechanisms in the 6-Hz psychomotor seizures in mice" @default.
• W2902322013 cites W1595266116 @default.
• W2902322013 cites W1968524204 @default.
• W2902322013 cites W1971248623 @default.
• W2902322013 cites W1980136039 @default.
• W2902322013 cites W1985056740 @default.
• W2902322013 cites W1987018944 @default.
• W2902322013 cites W1988760460 @default.
• W2902322013 cites W1989265374 @default.
• W2902322013 cites W1990991409 @default.
• W2902322013 cites W1996231894 @default.
• W2902322013 cites W2000972310 @default.
• W2902322013 cites W2017061363 @default.
• W2902322013 cites W2017398416 @default.
• W2902322013 cites W2024536613 @default.
• W2902322013 cites W2032091102 @default.
• W2902322013 cites W2033043593 @default.
• W2902322013 cites W2057368032 @default.
• W2902322013 cites W2060353913 @default.
• W2902322013 cites W2062703583 @default.
• W2902322013 cites W2062785942 @default.
• W2902322013 cites W2064765037 @default.
• W2902322013 cites W2066370985 @default.
• W2902322013 cites W2088694995 @default.
• W2902322013 cites W2092531573 @default.
• W2902322013 cites W2100283245 @default.
• W2902322013 cites W2129719693 @default.
• W2902322013 cites W2133744751 @default.
• W2902322013 cites W2137826748 @default.
• W2902322013 cites W2149367214 @default.
• W2902322013 cites W2164573587 @default.
• W2902322013 cites W2231780556 @default.
• W2902322013 cites W2468804098 @default.
• W2902322013 cites W2593433399 @default.
• W2902322013 cites W2735289373 @default.
• W2902322013 doi "https://doi.org/10.1177/0960327118814149" @default.
• W2902322013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30472898" @default.
• W2902322013 hasPublicationYear "2018" @default.
• W2902322013 type Work @default.
• W2902322013 sameAs 2902322013 @default.
• W2902322013 citedByCount "4" @default.
• W2902322013 countsByYear W29023220132020 @default.
• W2902322013 countsByYear W29023220132021 @default.
• W2902322013 countsByYear W29023220132022 @default.
• W2902322013 crossrefType "journal-article" @default.
• W2902322013 hasAuthorship W2902322013A5010126598 @default.
• W2902322013 hasAuthorship W2902322013A5018215309 @default.
• W2902322013 hasAuthorship W2902322013A5019144480 @default.
• W2902322013 hasConcept C100691959 @default.
• W2902322013 hasConcept C126322002 @default.
• W2902322013 hasConcept C134018914 @default.
• W2902322013 hasConcept C148762608 @default.
• W2902322013 hasConcept C15744967 @default.
• W2902322013 hasConcept C164953862 @default.
• W2902322013 hasConcept C169760540 @default.
• W2902322013 hasConcept C169900460 @default.
• W2902322013 hasConcept C170493617 @default.
• W2902322013 hasConcept C24998067 @default.
• W2902322013 hasConcept C2775864247 @default.
• W2902322013 hasConcept C2777448245 @default.
• W2902322013 hasConcept C2778186239 @default.
• W2902322013 hasConcept C2778646069 @default.
• W2902322013 hasConcept C2779994606 @default.
• W2902322013 hasConcept C2781161787 @default.
• W2902322013 hasConcept C37000724 @default.
• W2902322013 hasConcept C71924100 @default.
• W2902322013 hasConceptScore W2902322013C100691959 @default.
• W2902322013 hasConceptScore W2902322013C126322002 @default.
• W2902322013 hasConceptScore W2902322013C134018914 @default.
• W2902322013 hasConceptScore W2902322013C148762608 @default.
• W2902322013 hasConceptScore W2902322013C15744967 @default.
• W2902322013 hasConceptScore W2902322013C164953862 @default.
• W2902322013 hasConceptScore W2902322013C169760540 @default.
• W2902322013 hasConceptScore W2902322013C169900460 @default.
• W2902322013 hasConceptScore W2902322013C170493617 @default.
• W2902322013 hasConceptScore W2902322013C24998067 @default.
• W2902322013 hasConceptScore W2902322013C2775864247 @default.
• W2902322013 hasConceptScore W2902322013C2777448245 @default.
• W2902322013 hasConceptScore W2902322013C2778186239 @default.
• W2902322013 hasConceptScore W2902322013C2778646069 @default.
• W2902322013 hasConceptScore W2902322013C2779994606 @default.
• W2902322013 hasConceptScore W2902322013C2781161787 @default.
• W2902322013 hasConceptScore W2902322013C37000724 @default.
• W2902322013 hasConceptScore W2902322013C71924100 @default.
• W2902322013 hasFunder F4320320720 @default.
• W2902322013 hasIssue "3" @default.
• W2902322013 hasLocation W29023220131 @default.
• W2902322013 hasLocation W29023220132 @default.
• W2902322013 hasOpenAccess W2902322013 @default.
• W2902322013 hasPrimaryLocation W29023220131 @default.
• W2902322013 hasRelatedWork W1984841954 @default.

• next