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- W2902330895 abstract "Natural Killer (NK) cells suppress tumor initiation and metastasis. Most carcinomas are heterogeneous mixtures of epithelial, mesenchymal and hybrid tumor cells, but the relationships of these phenotypes to NK susceptibility are understood incompletely. Grainyhead-like-2 (GRHL2) is a master programmer of the epithelial phenotype, that is obligatorily down-regulated during experimentally induced Epithelial-Mesenchymal Transition (EMT). Here, we utilize GRHL2 re-expression to discover unifying molecular mechanisms that link the epithelial phenotype with NK-sensitivity. GRHL2 enhanced the expression of ICAM-1, augmenting NK-target cell synaptogenesis and NK killing of target cells. The expression of multiple interferon response genes, including ICAM1, anti-correlated with EMT. We identified two novel GRHL2-interacting proteins, the histone methyltransferases KMT2C and KMT2D. Mesenchymal-epithelial transition, NK-sensitization and ICAM-1 expression were promoted by GRHL2-KMT2C/D interactions and by GRHL2 inhibition of p300, revealing novel and potentially targetable epigenetic mechanisms connecting the epithelial phenotype with target cell susceptibility to NK killing." @default.
- W2902330895 created "2018-12-11" @default.
- W2902330895 creator A5013849303 @default.
- W2902330895 creator A5018718250 @default.
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- W2902330895 creator A5023047079 @default.
- W2902330895 creator A5028610485 @default.
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- W2902330895 creator A5068581807 @default.
- W2902330895 creator A5070978444 @default.
- W2902330895 creator A5085890841 @default.
- W2902330895 date "2019-01-01" @default.
- W2902330895 modified "2023-09-27" @default.
- W2902330895 title "Grainyhead-like-2 confers NK-sensitivity through interactions with epigenetic modifiers" @default.
- W2902330895 cites W1045355598 @default.
- W2902330895 cites W1491394604 @default.
- W2902330895 cites W1931518331 @default.
- W2902330895 cites W1976324983 @default.
- W2902330895 cites W1984164650 @default.
- W2902330895 cites W1987965170 @default.
- W2902330895 cites W1996863944 @default.
- W2902330895 cites W2004373794 @default.
- W2902330895 cites W2007693561 @default.
- W2902330895 cites W2011092598 @default.
- W2902330895 cites W2013782945 @default.
- W2902330895 cites W2028226531 @default.
- W2902330895 cites W2040401602 @default.
- W2902330895 cites W2049857616 @default.
- W2902330895 cites W2052313621 @default.
- W2902330895 cites W2054072489 @default.
- W2902330895 cites W2058763255 @default.
- W2902330895 cites W2073070336 @default.
- W2902330895 cites W2073404665 @default.
- W2902330895 cites W2090332697 @default.
- W2902330895 cites W2101538692 @default.
- W2902330895 cites W2108318095 @default.
- W2902330895 cites W2113172016 @default.
- W2902330895 cites W2114154136 @default.
- W2902330895 cites W2114843025 @default.
- W2902330895 cites W2121158603 @default.
- W2902330895 cites W2122236081 @default.
- W2902330895 cites W2128402485 @default.
- W2902330895 cites W2153932894 @default.
- W2902330895 cites W2157005857 @default.
- W2902330895 cites W2159235132 @default.
- W2902330895 cites W2164618834 @default.
- W2902330895 cites W2166218648 @default.
- W2902330895 cites W2166649117 @default.
- W2902330895 cites W2169105660 @default.
- W2902330895 cites W2173799933 @default.
- W2902330895 cites W2221432805 @default.
- W2902330895 cites W2269247182 @default.
- W2902330895 cites W2275249553 @default.
- W2902330895 cites W2277039327 @default.
- W2902330895 cites W2288921756 @default.
- W2902330895 cites W2289283229 @default.
- W2902330895 cites W2298503769 @default.
- W2902330895 cites W2299181842 @default.
- W2902330895 cites W2314851760 @default.
- W2902330895 cites W2341622558 @default.
- W2902330895 cites W2375577403 @default.
- W2902330895 cites W2411481262 @default.
- W2902330895 cites W2419237034 @default.
- W2902330895 cites W2522313999 @default.
- W2902330895 cites W2527140315 @default.
- W2902330895 cites W2555771555 @default.
- W2902330895 cites W2559785292 @default.
- W2902330895 cites W2559885684 @default.
- W2902330895 cites W2567281524 @default.
- W2902330895 cites W2570010463 @default.
- W2902330895 cites W2571183003 @default.
- W2902330895 cites W2576512904 @default.
- W2902330895 cites W2586736965 @default.
- W2902330895 cites W2594836176 @default.
- W2902330895 cites W2595145824 @default.
- W2902330895 cites W2601176113 @default.
- W2902330895 cites W2604022024 @default.
- W2902330895 cites W2605607341 @default.
- W2902330895 cites W2611178729 @default.
- W2902330895 cites W2611717200 @default.
- W2902330895 cites W2615262442 @default.
- W2902330895 cites W2638401050 @default.
- W2902330895 cites W2727463864 @default.
- W2902330895 cites W2728031786 @default.
- W2902330895 cites W2734605359 @default.
- W2902330895 cites W2739001429 @default.
- W2902330895 cites W2744743363 @default.
- W2902330895 cites W2748446253 @default.
- W2902330895 cites W2758897789 @default.
- W2902330895 cites W2783337717 @default.
- W2902330895 cites W2786535550 @default.
- W2902330895 cites W2788975052 @default.
- W2902330895 cites W2790935413 @default.
- W2902330895 cites W2792403564 @default.
- W2902330895 cites W2794348835 @default.
- W2902330895 cites W2803792092 @default.