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- W2902364657 abstract "Background: Parkinson’s disease (PD) is a progressive neurodegenerative disease, affecting over 1% of individuals over the age of 60 years. Approximately 90% of the PD cases are idiopathic, where the etiology is multifactorial and caused by gene-environment interactions. Exposure to various environmental factors have seen to be strongly associated with an increased or decreased PD risk. We aimed to investigate these factors and their association to PD in the Multipark’s biobank sample collection, a case-control cohort from the southernmost province of Sweden, Skane. Methods: A matched case-control study design was conducted where a total of 945 PD patients and 945 controls where included. Comparison of life style, habits, and environmental exposure between patients and controls was performed. For statistically significant variables, the association with PD was studied using conditional logistic regression analysis. Results: Pesticide exposure was significantly associated with an increased PD risk. A family history of PD was significantly overrepresented among the patients. Smoking and snus use were both inversely significantly associated with the risk of PD. A statistically significant difference was seen between patients and controls for previous head trauma, and coffee consumption. Conclusion: The obtained result from this study will be a valuable resource for various field within PD research, i.e., genetics, where analysis of gene-environment interactions and PD risk can be performed in the future. (Less)" @default.
- W2902364657 created "2018-12-11" @default.
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- W2902364657 date "2018-01-01" @default.
- W2902364657 modified "2023-09-24" @default.
- W2902364657 title "Multipark’s biobank sample collection: A Swedish case-control study on Parkinson’s disease" @default.
- W2902364657 hasPublicationYear "2018" @default.
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