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• W2902402532 startingPage "628" @default.
• W2902402532 abstract "Men diagnosed with localized prostate cancer have many curative treatment options including several different radiotherapeutic approaches. Proton radiation is one such radiation treatment modality and, due to its unique physical properties, offers the appealing potential of reduced side effects without sacrificing cancer control. In this review, we examine the intriguing dosimetric rationale and theoretical benefit of proton radiation for prostate cancer and highlight the results of preclinical modeling studies. We then discuss the current state of the clinical evidence for proton efficacy and toxicity, derived from both large claim-based datasets and prospective patient-reported data. The result is that the data are mixed, and clinical equipoise persists in this area. We place these studies into context by summarizing the economics of proton therapy and the changing practice patterns of prostate proton irradiation. Finally, we await the results of a large prospective randomized clinical trial currently accruing and also a large prospective pragmatic comparative study which will provide more rigorous evidence regarding the clinical and comparative effectiveness of proton therapy for prostate cancer." @default.
• W2902402532 created "2018-12-11" @default.
• W2902402532 creator A5048513152 @default.
• W2902402532 creator A5053191395 @default.
• W2902402532 date "2019-09-01" @default.
• W2902402532 modified "2023-10-02" @default.
• W2902402532 title "Proton therapy for prostate cancer: A review of the rationale, evidence, and current state" @default.
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• W2902402532 doi "https://doi.org/10.1016/j.urolonc.2018.11.012" @default.
• W2902402532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30527342" @default.
• W2902402532 hasPublicationYear "2019" @default.
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