FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2902436102> ?p ?o ?g. }

• W2902436102 endingPage "908" @default.
• W2902436102 startingPage "903" @default.
• W2902436102 abstract "Pro-protein convertase subtilisin/kexin type 9 (PCSK9) inhibitors bring about a wide reduction in low-density lipoprotein (LDL) cholesterol, greater than that of other lipid-lowering agents. The aim of this metanalysis was assessment of the effects of PCSK9 inhibitors on glucose metabolism, LDL cholesterol, cardiovascular morbidity and mortality in individuals with and without diabetes.A Medline and Clinicaltrials.gov search for eligible studies published before 1 December 2017 was performed. All randomized trials comparing PCSK-9 inhibitors with placebo or active drugs were included. Primary endpoints included (a) incident diabetes, fasting glucose and HbA1c, (b) LDL cholesterol at endpoint in patients with diabetes and in the total sample, and (c) major cardiovascular events (MACE) and mortality in individuals with and without diabetes.A total of 38 trials was identified. The risk of incident diabetes was not increased by PCSK-9 inhibitors, vs placebo or any comparator. The reduction in LDL cholesterol vs placebo in patients with diabetes was 52.6 [41.3;63.8] mg/dL; the corresponding figure for all patients was 66.9 [62.4;71.3] mg/dL. Meta-regression analysis showed an inverse correlation between proportion of patients with diabetes and drug effect on LDL cholesterol in trials vs ezetimibe, but not in those vs placebo. In studies reporting data on MACE and mortality separately for individuals with and without diabetes, the effect of PCSK-9 did not appear to be affected by diabetes.PCSK-9 inhibitors do not affect glucose metabolism. Their efficacy on LDL cholesterol and MACE in patients with diabetes does not seem to be very dissimilar to that observed in non-diabetic participants." @default.
• W2902436102 created "2018-12-11" @default.
• W2902436102 creator A5059413618 @default.
• W2902436102 creator A5059685674 @default.
• W2902436102 creator A5084623347 @default.
• W2902436102 date "2019-04-01" @default.
• W2902436102 modified "2023-09-29" @default.
• W2902436102 title "PCSK9 inhibitor therapy: A systematic review and meta‐analysis of metabolic and cardiovascular outcomes in patients with diabetes" @default.
• W2902436102 cites W1423581981 @default.
• W2902436102 cites W1816597323 @default.
• W2902436102 cites W1890541571 @default.
• W2902436102 cites W1986215651 @default.
• W2902436102 cites W2019392263 @default.
• W2902436102 cites W2046181127 @default.
• W2902436102 cites W2097870088 @default.
• W2902436102 cites W2115752151 @default.
• W2902436102 cites W2134833483 @default.
• W2902436102 cites W2140272923 @default.
• W2902436102 cites W2141898196 @default.
• W2902436102 cites W2156098321 @default.
• W2902436102 cites W2157838461 @default.
• W2902436102 cites W2164089346 @default.
• W2902436102 cites W2175943040 @default.
• W2902436102 cites W2266600614 @default.
• W2902436102 cites W2306356166 @default.
• W2902436102 cites W2507042026 @default.
• W2902436102 cites W2569114271 @default.
• W2902436102 cites W2618542302 @default.
• W2902436102 cites W2754562397 @default.
• W2902436102 cites W2756174617 @default.
• W2902436102 cites W2780743843 @default.
• W2902436102 cites W2787959738 @default.
• W2902436102 cites W2790059086 @default.
• W2902436102 cites W2795638059 @default.
• W2902436102 cites W2800932705 @default.
• W2902436102 cites W2803816352 @default.
• W2902436102 cites W2991792334 @default.
• W2902436102 doi "https://doi.org/10.1111/dom.13599" @default.
• W2902436102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30485622" @default.
• W2902436102 hasPublicationYear "2019" @default.
• W2902436102 type Work @default.
• W2902436102 sameAs 2902436102 @default.
• W2902436102 citedByCount "36" @default.
• W2902436102 countsByYear W29024361022019 @default.
• W2902436102 countsByYear W29024361022020 @default.
• W2902436102 countsByYear W29024361022021 @default.
• W2902436102 countsByYear W29024361022022 @default.
• W2902436102 countsByYear W29024361022023 @default.
• W2902436102 crossrefType "journal-article" @default.
• W2902436102 hasAuthorship W2902436102A5059413618 @default.
• W2902436102 hasAuthorship W2902436102A5059685674 @default.
• W2902436102 hasAuthorship W2902436102A5084623347 @default.
• W2902436102 hasConcept C126322002 @default.
• W2902436102 hasConcept C134018914 @default.
• W2902436102 hasConcept C142724271 @default.
• W2902436102 hasConcept C204787440 @default.
• W2902436102 hasConcept C27081682 @default.
• W2902436102 hasConcept C2777180221 @default.
• W2902436102 hasConcept C2778163477 @default.
• W2902436102 hasConcept C2778657065 @default.
• W2902436102 hasConcept C2780072125 @default.
• W2902436102 hasConcept C2780739214 @default.
• W2902436102 hasConcept C2780948078 @default.
• W2902436102 hasConcept C43554185 @default.
• W2902436102 hasConcept C45393284 @default.
• W2902436102 hasConcept C500558357 @default.
• W2902436102 hasConcept C555293320 @default.
• W2902436102 hasConcept C71924100 @default.
• W2902436102 hasConceptScore W2902436102C126322002 @default.
• W2902436102 hasConceptScore W2902436102C134018914 @default.
• W2902436102 hasConceptScore W2902436102C142724271 @default.
• W2902436102 hasConceptScore W2902436102C204787440 @default.
• W2902436102 hasConceptScore W2902436102C27081682 @default.
• W2902436102 hasConceptScore W2902436102C2777180221 @default.
• W2902436102 hasConceptScore W2902436102C2778163477 @default.
• W2902436102 hasConceptScore W2902436102C2778657065 @default.
• W2902436102 hasConceptScore W2902436102C2780072125 @default.
• W2902436102 hasConceptScore W2902436102C2780739214 @default.
• W2902436102 hasConceptScore W2902436102C2780948078 @default.
• W2902436102 hasConceptScore W2902436102C43554185 @default.
• W2902436102 hasConceptScore W2902436102C45393284 @default.
• W2902436102 hasConceptScore W2902436102C500558357 @default.
• W2902436102 hasConceptScore W2902436102C555293320 @default.
• W2902436102 hasConceptScore W2902436102C71924100 @default.
• W2902436102 hasIssue "4" @default.
• W2902436102 hasLocation W29024361021 @default.
• W2902436102 hasLocation W29024361022 @default.
• W2902436102 hasOpenAccess W2902436102 @default.
• W2902436102 hasPrimaryLocation W29024361021 @default.
• W2902436102 hasRelatedWork W161816689 @default.
• W2902436102 hasRelatedWork W2005998106 @default.
• W2902436102 hasRelatedWork W2032958076 @default.
• W2902436102 hasRelatedWork W2035331946 @default.
• W2902436102 hasRelatedWork W2075372262 @default.
• W2902436102 hasRelatedWork W2103647780 @default.
• W2902436102 hasRelatedWork W2127396703 @default.
• W2902436102 hasRelatedWork W2153591790 @default.
• W2902436102 hasRelatedWork W2158288207 @default.

• next