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- W2902437314 abstract "Cochlear implants interface with the fluid in the cochlea called perilymph. The volume of this fluid present in human and animal model cochlea is prohibitively low for isolation for in vitro studies. Thus, there is a need for an artificial perilymph that reflects the complexity of this fluid in terms of competitive protein adsorption.This study established a biomimetic artificial perilymph (BAP) comprising serum albumin, immunoglobulin G, transferrin, inter-alpha-trypsin inhibitor, apolipoprotein A1 and complement C3 to represent the major components of human perilymph. Adsorption of the BAP components to platinum was analysed.It was established that this six component BAP provided competitive and complex adsorption behaviours consistent with biologically derived complex fluids. Additionally, adsorption of the BAP components to platinum cochlear electrodes resulted in a change in polarisation impedance consistent with that observed for the cochlear device in vivo.This study established a BAP fluid suitable for furthering the understanding of the implant environment for electroactive devices that interface with the biological environment." @default.
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- W2902437314 date "2019-01-23" @default.
- W2902437314 modified "2023-09-23" @default.
- W2902437314 title "Development and performance of a biomimetic artificial perilymph for<i>in vitro</i>testing of medical devices" @default.
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- W2902437314 doi "https://doi.org/10.1088/1741-2552/aaf482" @default.
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