Matches in SemOpenAlex for { <https://semopenalex.org/work/W2902439462> ?p ?o ?g. }
- W2902439462 endingPage "8763" @default.
- W2902439462 startingPage "8754" @default.
- W2902439462 abstract "Bone morphogenetic protein (BMP)2/7 heterodimer shows greater efficacy in enhancing bone regeneration. However, the precise mechanism and the role of mitogen-activated protein kinase (MAPK) signaling network in BMP2/7-driven osteogenesis remain ambiguous. In this study, we evaluated the effects of BMP2/7 heterodimers on osteoblastic differentiation in rat bone marrow mesenchymal stem cells (BMSCs), with the aim to elaborate how MAPKs might be involved in this cellular process by treatment of rat BMSCs with BMP2/-7 with a special signal-pathway inhibitor. We found that BMP2/7 heterodimer induced a much stronger osteogenic response in rat BMSCs compared with either homodimer. Most interestingly, extracellular signal-regulated kinase (ERK) demonstrated a highly sustained phosphorylation and activation in the BMP2/7 heterodimer treatment groups, and inhibition of ERK cascades using U0126 special inhibitor that significantly reduced the activity of ALP and calcium mineralization to a substantial degree in rat BMSCs treated with BMP2/7 heterodimers. Collectively, we demonstrate that BMP2/7 heterodimer shows a potent ability to stimulate osteogenesis in rat BMSCs. The activated ERK signaling pathway involved in this process may contribute partially to an increased osteogenic potency of heterodimeric BMP2/7 growth factors." @default.
- W2902439462 created "2018-12-11" @default.
- W2902439462 creator A5005821883 @default.
- W2902439462 creator A5006988702 @default.
- W2902439462 creator A5013292654 @default.
- W2902439462 creator A5018293897 @default.
- W2902439462 creator A5025266656 @default.
- W2902439462 creator A5041025847 @default.
- W2902439462 creator A5058587275 @default.
- W2902439462 creator A5060174737 @default.
- W2902439462 creator A5070085914 @default.
- W2902439462 creator A5070623919 @default.
- W2902439462 creator A5078348857 @default.
- W2902439462 creator A5089198168 @default.
- W2902439462 creator A5090724679 @default.
- W2902439462 date "2018-11-28" @default.
- W2902439462 modified "2023-10-18" @default.
- W2902439462 title "BMP2/7 heterodimer enhances osteogenic differentiation of rat BMSCs via ERK signaling compared with respective homodimers" @default.
- W2902439462 cites W1508777555 @default.
- W2902439462 cites W1528120845 @default.
- W2902439462 cites W1912814873 @default.
- W2902439462 cites W1965711514 @default.
- W2902439462 cites W1966639987 @default.
- W2902439462 cites W1968521370 @default.
- W2902439462 cites W1972344669 @default.
- W2902439462 cites W1974423029 @default.
- W2902439462 cites W1997480784 @default.
- W2902439462 cites W1998140357 @default.
- W2902439462 cites W2008915544 @default.
- W2902439462 cites W2019777614 @default.
- W2902439462 cites W2024936019 @default.
- W2902439462 cites W2038292652 @default.
- W2902439462 cites W2038483458 @default.
- W2902439462 cites W2045318349 @default.
- W2902439462 cites W2046535293 @default.
- W2902439462 cites W2053296763 @default.
- W2902439462 cites W2061635827 @default.
- W2902439462 cites W2068872259 @default.
- W2902439462 cites W2118089919 @default.
- W2902439462 cites W2120033390 @default.
- W2902439462 cites W2134295691 @default.
- W2902439462 cites W2138075395 @default.
- W2902439462 cites W2156682347 @default.
- W2902439462 cites W2178641192 @default.
- W2902439462 cites W2280022771 @default.
- W2902439462 cites W2525414772 @default.
- W2902439462 cites W2738065173 @default.
- W2902439462 cites W3000473592 @default.
- W2902439462 cites W4244095134 @default.
- W2902439462 doi "https://doi.org/10.1002/jcb.28162" @default.
- W2902439462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30485526" @default.
- W2902439462 hasPublicationYear "2018" @default.
- W2902439462 type Work @default.
- W2902439462 sameAs 2902439462 @default.
- W2902439462 citedByCount "12" @default.
- W2902439462 countsByYear W29024394622019 @default.
- W2902439462 countsByYear W29024394622020 @default.
- W2902439462 countsByYear W29024394622021 @default.
- W2902439462 countsByYear W29024394622022 @default.
- W2902439462 countsByYear W29024394622023 @default.
- W2902439462 crossrefType "journal-article" @default.
- W2902439462 hasAuthorship W2902439462A5005821883 @default.
- W2902439462 hasAuthorship W2902439462A5006988702 @default.
- W2902439462 hasAuthorship W2902439462A5013292654 @default.
- W2902439462 hasAuthorship W2902439462A5018293897 @default.
- W2902439462 hasAuthorship W2902439462A5025266656 @default.
- W2902439462 hasAuthorship W2902439462A5041025847 @default.
- W2902439462 hasAuthorship W2902439462A5058587275 @default.
- W2902439462 hasAuthorship W2902439462A5060174737 @default.
- W2902439462 hasAuthorship W2902439462A5070085914 @default.
- W2902439462 hasAuthorship W2902439462A5070623919 @default.
- W2902439462 hasAuthorship W2902439462A5078348857 @default.
- W2902439462 hasAuthorship W2902439462A5089198168 @default.
- W2902439462 hasAuthorship W2902439462A5090724679 @default.
- W2902439462 hasConcept C104317684 @default.
- W2902439462 hasConcept C11960822 @default.
- W2902439462 hasConcept C184235292 @default.
- W2902439462 hasConcept C185592680 @default.
- W2902439462 hasConcept C198826908 @default.
- W2902439462 hasConcept C202751555 @default.
- W2902439462 hasConcept C2776363554 @default.
- W2902439462 hasConcept C2778260815 @default.
- W2902439462 hasConcept C30352789 @default.
- W2902439462 hasConcept C31507581 @default.
- W2902439462 hasConcept C55493867 @default.
- W2902439462 hasConcept C57074206 @default.
- W2902439462 hasConcept C62478195 @default.
- W2902439462 hasConcept C86803240 @default.
- W2902439462 hasConcept C95444343 @default.
- W2902439462 hasConcept C97029542 @default.
- W2902439462 hasConceptScore W2902439462C104317684 @default.
- W2902439462 hasConceptScore W2902439462C11960822 @default.
- W2902439462 hasConceptScore W2902439462C184235292 @default.
- W2902439462 hasConceptScore W2902439462C185592680 @default.
- W2902439462 hasConceptScore W2902439462C198826908 @default.
- W2902439462 hasConceptScore W2902439462C202751555 @default.
- W2902439462 hasConceptScore W2902439462C2776363554 @default.
- W2902439462 hasConceptScore W2902439462C2778260815 @default.