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- W2902445105 abstract "The Ethylene-responsive element binding factor-associated Amphiphilic Repression (EAR) motifs, which were initially identified in members of the Arabidopsis ethylene response factor (ERF) family, are transcriptional repression motifs in plants and are defined by the consensus sequence patterns of either LxLxL or DLNxxP. EAR motif-containing proteins can function as transcription repressors, thus interacting with co-repressors, such as TOPLESS and AtSAP18, affecting the structure of chromatin by histone modifications and thereby repressing gene transcription. EAR motif-containing proteins are highly conserved across diverse plant species and play important roles in hormone signal transduction, stress responses and development, but they have not been identified in most plants. In this study, we identified 20,542 EAR motif-containing proteins from 71 plants based on a Hidden Markov Model and orthologous gene search, and then we constructed a functional analysis platform for plant EAR motif-containing proteins (PlantEAR, http://structuralbiology.cau.edu.cn/plantEAR) by integrating a variety of functional annotations and processed data. Several tools were provided as functional support for EAR motif-containing proteins, such as browse, search, co-expression and protein-protein interaction (PPI) network analysis as well as cis-element analysis and gene set enrichment analysis (GSEA). In addition, basing on the identified EAR motif-containing proteins, we also explored their distribution in various species and found that the numbers of EAR motif-containing proteins showed an increasing trend in evolution from algae to angiosperms." @default.
- W2902445105 created "2018-12-11" @default.
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- W2902445105 date "2018-11-30" @default.
- W2902445105 modified "2023-10-12" @default.
- W2902445105 title "PlantEAR: Functional Analysis Platform for Plant EAR Motif-Containing Proteins" @default.
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- W2902445105 doi "https://doi.org/10.3389/fgene.2018.00590" @default.
- W2902445105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6283911" @default.
- W2902445105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30555515" @default.
- W2902445105 hasPublicationYear "2018" @default.
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