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• W2902461092 abstract "Objective: To evaluate the safety and efficacy of statins in an Indian population attending a cardiology clinic and thereby assess the utilization pattern of the drugs.Study design: It is a prospective study.Study setting: The study was conducted in Department of Cardiology, Kovai Medical Center and Hospital in Coimbatore, Tamil NaduStudy period: The study was conducted over a period of 6 months from July 2011 to December 2011Inclusion criteria: All patients diagnosed with dyslipidemia and cardiovascular risk factors, prescribed with statins for the first time in the Department of Cardiology, Kovai Medical Center Hospital Coimbatore.Exclusion criteria : Patients who were previously on Statin therapy will be excluded from the study and Patients without a lipid profile at their first review. CONCLUSION: The aim of the study was to assess the statin use in an Indian clinical setting in terms of class, dose, and type of prevention and monitoring of Adverse Drug Reactions. In the study population atorvastatin was prescribed in 78.12% of patients and rosuvastatin was prescribed in 28.87% of the patients only. Most of the patients are prescribed with atorvastatin 40mg (28.12%) and the least number of patients were prescribed with rosuvastatin 20mg (3.12%).The lipid reduction properties of statins were assessed by measuring the LDL-C level of the patients at baseline and at review. The study revealed that at review, atorvastatin showed a significant reduction in LDL-C level from the baseline at prescribed doses 10mg, 40mg, and 80mg. There was a substantial reduction in the LDL-C level from the baseline in the patients prescribed with atorvastatin 5mg and rosuvastatin 10mg at review, eventhough the reduction was found to be non significant.The study was also aimed to check the efficacy of statin to achieve the target LDL-C level of the patients and it was found that 93.75% of the patients achieved their target LDL-C level on treatment with statins. The Adverse Drug Reactions were monitored and related to different characteristics of the study population. The main ADR found in the study population was muscle pain and was predominant in the age group of 61-70 years. The baseline LDL-C of the patients prescribed with atorvastatin 10mg (145.25±21.96) was found to be higher than that of the patients with atorvastatin 40mg (101.77±12.24).The adherence of the patients to prescribed statin was checked by using Morisky‟s-8 questionnaire and it was found that 67.4 % of patients were highly adherent to their treatment plan. 22.58% of patients showed medium adherence and 9.67% of patients showed low adherence to their treatment plans." @default.
• W2902461092 created "2018-12-11" @default.
• W2902461092 creator A5026604927 @default.
• W2902461092 date "2012-04-01" @default.
• W2902461092 modified "2023-09-24" @default.
• W2902461092 title "Utilization Pattern of Statins in an Indian Population." @default.
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