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• W2902463392 abstract "hERG (Human ether-a-go-go-related gene) potassium channel, which plays an essential role in cardiac action potential repolarization, is responsible for inherited and druginduced long QT syndrome. Recently, the Cryo-EM structure capturing the open conformation of hERG channel was determined, thus pushing the study on hERG channel at 3.8 Å resolution. This report focuses primarily on summarizing the design rationale and application of several fluorescent probes that target hERG channels, which enables dynamic and real-time monitoring of potassium pore channel affinity to further advance the understanding of the channels." @default.
• W2902463392 created "2018-12-11" @default.
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• W2902463392 date "2020-06-03" @default.
• W2902463392 modified "2023-09-23" @default.
• W2902463392 title "How to Fluorescently Label the Potassium Channel: A Case in hERG" @default.
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• W2902463392 doi "https://doi.org/10.2174/0929867326666181129094455" @default.
• W2902463392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30488791" @default.
• W2902463392 hasPublicationYear "2020" @default.
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