FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2902488785> ?p ?o ?g. }

• W2902488785 endingPage "100" @default.
• W2902488785 startingPage "88" @default.
• W2902488785 abstract "Background and Objectives The aim of the study was to understand the importance of mismatch repair genes MLH1 and MSH2 in chemotolerance and prognosis of breast carcinoma (BC). Methods First, the alterations (deletion/methylation/expression) of MLH1 and MSH2 were analyzed in 45 neoadjuvant chemotherapy (NACT)‐treated and 133 pretherapeutic BC samples. The chemotolerant BC cells were characterized by treating two BC cell lines MCF‐7 and MDA MB 231 with two anthracycline antitumor antibiotics, doxorubicin and nogalamycin. Results The deletion frequencies were 32% to 38% in MLH1/MSH2 genes and promoter methylation frequencies were 49% to 62% in MLH1 and 41% to 51% in MSH2 in both NACT‐treated and pretherapeutic samples. The overall alteration of MLH1 and MSH2 was 58% to 71% in the samples. Reduced messenger RNA (mRNA) and protein expression were found in both the genes and it showed concordance with the molecular alterations. NACT‐treated patients showed better prognosis. The chemotherapeutic drug induced increased mRNA/protein expression of the genes in BC cell lines was due to their promoter hypomethylation, as analyzed by quantitative methylation assay. This phenomenon was also evident in NACT‐treated BC samples. Conclusion MLH1/MSH2 genes play a critical role in the development of BC. Hypomethylation of MLH1/MSH2 genes might be important in chemotolerance of the disease." @default.
• W2902488785 created "2018-12-11" @default.
• W2902488785 creator A5008328391 @default.
• W2902488785 creator A5011589978 @default.
• W2902488785 creator A5024345928 @default.
• W2902488785 creator A5045381779 @default.
• W2902488785 creator A5077206543 @default.
• W2902488785 creator A5088425861 @default.
• W2902488785 date "2018-11-27" @default.
• W2902488785 modified "2023-09-30" @default.
• W2902488785 title "Hypomethylation of mismatch repair genes MLH1 and MSH2 is associated with chemotolerance of breast carcinoma: Clinical significance" @default.
• W2902488785 cites W1595797072 @default.
• W2902488785 cites W1713917971 @default.
• W2902488785 cites W1861883318 @default.
• W2902488785 cites W1890648625 @default.
• W2902488785 cites W1965680994 @default.
• W2902488785 cites W1965905627 @default.
• W2902488785 cites W1966366887 @default.
• W2902488785 cites W1977353315 @default.
• W2902488785 cites W1982449999 @default.
• W2902488785 cites W2007100761 @default.
• W2902488785 cites W2016252161 @default.
• W2902488785 cites W2016926578 @default.
• W2902488785 cites W2020970310 @default.
• W2902488785 cites W2026250135 @default.
• W2902488785 cites W2027051482 @default.
• W2902488785 cites W2035717945 @default.
• W2902488785 cites W2039330198 @default.
• W2902488785 cites W2044946449 @default.
• W2902488785 cites W2050629268 @default.
• W2902488785 cites W2054807590 @default.
• W2902488785 cites W2066024784 @default.
• W2902488785 cites W2073981345 @default.
• W2902488785 cites W2075106532 @default.
• W2902488785 cites W2076139950 @default.
• W2902488785 cites W2082604067 @default.
• W2902488785 cites W2085947779 @default.
• W2902488785 cites W2090810603 @default.
• W2902488785 cites W2097096572 @default.
• W2902488785 cites W2104356108 @default.
• W2902488785 cites W2106391833 @default.
• W2902488785 cites W2107277218 @default.
• W2902488785 cites W2112337406 @default.
• W2902488785 cites W2114105734 @default.
• W2902488785 cites W2114570899 @default.
• W2902488785 cites W2126663390 @default.
• W2902488785 cites W2128500791 @default.
• W2902488785 cites W2137569018 @default.
• W2902488785 cites W2139340804 @default.
• W2902488785 cites W2162964765 @default.
• W2902488785 cites W2467260024 @default.
• W2902488785 cites W2522691823 @default.
• W2902488785 cites W2889929061 @default.
• W2902488785 doi "https://doi.org/10.1002/jso.25304" @default.
• W2902488785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30481381" @default.
• W2902488785 hasPublicationYear "2018" @default.
• W2902488785 type Work @default.
• W2902488785 sameAs 2902488785 @default.
• W2902488785 citedByCount "14" @default.
• W2902488785 countsByYear W29024887852020 @default.
• W2902488785 countsByYear W29024887852021 @default.
• W2902488785 countsByYear W29024887852022 @default.
• W2902488785 countsByYear W29024887852023 @default.
• W2902488785 crossrefType "journal-article" @default.
• W2902488785 hasAuthorship W2902488785A5008328391 @default.
• W2902488785 hasAuthorship W2902488785A5011589978 @default.
• W2902488785 hasAuthorship W2902488785A5024345928 @default.
• W2902488785 hasAuthorship W2902488785A5045381779 @default.
• W2902488785 hasAuthorship W2902488785A5077206543 @default.
• W2902488785 hasAuthorship W2902488785A5088425861 @default.
• W2902488785 hasBestOaLocation W29024887851 @default.
• W2902488785 hasConcept C104317684 @default.
• W2902488785 hasConcept C111425858 @default.
• W2902488785 hasConcept C121608353 @default.
• W2902488785 hasConcept C126322002 @default.
• W2902488785 hasConcept C134935766 @default.
• W2902488785 hasConcept C153911025 @default.
• W2902488785 hasConcept C2776674815 @default.
• W2902488785 hasConcept C2776694085 @default.
• W2902488785 hasConcept C2779115348 @default.
• W2902488785 hasConcept C2781303535 @default.
• W2902488785 hasConcept C3018521938 @default.
• W2902488785 hasConcept C33288867 @default.
• W2902488785 hasConcept C502942594 @default.
• W2902488785 hasConcept C530470458 @default.
• W2902488785 hasConcept C54355233 @default.
• W2902488785 hasConcept C60748783 @default.
• W2902488785 hasConcept C71924100 @default.
• W2902488785 hasConcept C86803240 @default.
• W2902488785 hasConceptScore W2902488785C104317684 @default.
• W2902488785 hasConceptScore W2902488785C111425858 @default.
• W2902488785 hasConceptScore W2902488785C121608353 @default.
• W2902488785 hasConceptScore W2902488785C126322002 @default.
• W2902488785 hasConceptScore W2902488785C134935766 @default.
• W2902488785 hasConceptScore W2902488785C153911025 @default.
• W2902488785 hasConceptScore W2902488785C2776674815 @default.
• W2902488785 hasConceptScore W2902488785C2776694085 @default.
• W2902488785 hasConceptScore W2902488785C2779115348 @default.

• next