FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2902515016> ?p ?o ?g. }

• W2902515016 abstract "Abstract Obesity increases the risk of hepatocellular carcinoma (HCC) especially in men, but the molecular mechanism remains obscure. Here, we show that an androgen receptor (AR)-driven oncogene, cell cycle-related kinase (CCRK), collaborates with obesity-induced pro-inflammatory signaling to promote non-alcoholic steatohepatitis (NASH)-related hepatocarcinogenesis. Lentivirus-mediated Ccrk ablation in liver of male mice fed with high-fat high-carbohydrate diet abrogates not only obesity-associated lipid accumulation, glucose intolerance and insulin resistance, but also HCC development. Mechanistically, CCRK fuels a feedforward loop by inducing STAT3-AR promoter co-occupancy and transcriptional up-regulation, which in turn activates mTORC1/4E-BP1/S6K/SREBP1 cascades via GSK3β phosphorylation. Moreover, hepatic CCRK induction in transgenic mice stimulates mTORC1-dependent G − csf expression to enhance polymorphonuclear myeloid-derived suppressor cell recruitment and tumorigenicity. Finally, the STAT3-AR-CCRK-mTORC1 pathway components are concordantly over-expressed in human NASH-associated HCCs. These findings unveil the dual roles of an inflammatory-CCRK circuitry in driving metabolic and immunosuppressive reprogramming through mTORC1 activation, thereby establishing a pro-tumorigenic microenvironment for HCC development." @default.
• W2902515016 created "2018-12-11" @default.
• W2902515016 creator A5002717367 @default.
• W2902515016 creator A5008000310 @default.
• W2902515016 creator A5025799914 @default.
• W2902515016 creator A5027409483 @default.
• W2902515016 creator A5033300046 @default.
• W2902515016 creator A5034189458 @default.
• W2902515016 creator A5035489872 @default.
• W2902515016 creator A5037378228 @default.
• W2902515016 creator A5042419460 @default.
• W2902515016 creator A5046486294 @default.
• W2902515016 creator A5046528197 @default.
• W2902515016 creator A5047819890 @default.
• W2902515016 creator A5049274840 @default.
• W2902515016 creator A5050867791 @default.
• W2902515016 creator A5053322097 @default.
• W2902515016 creator A5055538725 @default.
• W2902515016 creator A5056200578 @default.
• W2902515016 creator A5059065464 @default.
• W2902515016 creator A5061871732 @default.
• W2902515016 creator A5067295868 @default.
• W2902515016 creator A5067333447 @default.
• W2902515016 creator A5069044170 @default.
• W2902515016 creator A5070159050 @default.
• W2902515016 creator A5071159602 @default.
• W2902515016 creator A5072572231 @default.
• W2902515016 creator A5087968813 @default.
• W2902515016 date "2018-12-06" @default.
• W2902515016 modified "2023-10-18" @default.
• W2902515016 title "An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma" @default.
• W2902515016 cites W1523693806 @default.
• W2902515016 cites W1900105756 @default.
• W2902515016 cites W1973260880 @default.
• W2902515016 cites W1974439644 @default.
• W2902515016 cites W1982219839 @default.
• W2902515016 cites W1986219573 @default.
• W2902515016 cites W1986725817 @default.
• W2902515016 cites W1990376085 @default.
• W2902515016 cites W1995652213 @default.
• W2902515016 cites W1997901667 @default.
• W2902515016 cites W2000307707 @default.
• W2902515016 cites W2003379778 @default.
• W2902515016 cites W2007868505 @default.
• W2902515016 cites W2014533420 @default.
• W2902515016 cites W2018553282 @default.
• W2902515016 cites W2034200991 @default.
• W2902515016 cites W2037137226 @default.
• W2902515016 cites W2039845199 @default.
• W2902515016 cites W2039935344 @default.
• W2902515016 cites W2040962503 @default.
• W2902515016 cites W2045115988 @default.
• W2902515016 cites W2046136375 @default.
• W2902515016 cites W2052145855 @default.
• W2902515016 cites W2055832574 @default.
• W2902515016 cites W2065322400 @default.
• W2902515016 cites W2066462676 @default.
• W2902515016 cites W2067324334 @default.
• W2902515016 cites W2069436757 @default.
• W2902515016 cites W2074648434 @default.
• W2902515016 cites W2080998956 @default.
• W2902515016 cites W2084776235 @default.
• W2902515016 cites W2084875329 @default.
• W2902515016 cites W2091770605 @default.
• W2902515016 cites W2103190324 @default.
• W2902515016 cites W2112291880 @default.
• W2902515016 cites W2112662882 @default.
• W2902515016 cites W2113593386 @default.
• W2902515016 cites W2123218517 @default.
• W2902515016 cites W2125479243 @default.
• W2902515016 cites W2127063807 @default.
• W2902515016 cites W2132241298 @default.
• W2902515016 cites W2136795008 @default.
• W2902515016 cites W2141662760 @default.
• W2902515016 cites W2153607816 @default.
• W2902515016 cites W2155226662 @default.
• W2902515016 cites W2155824086 @default.
• W2902515016 cites W2159664830 @default.
• W2902515016 cites W2165806251 @default.
• W2902515016 cites W2289068089 @default.
• W2902515016 cites W2399999257 @default.
• W2902515016 cites W2488076079 @default.
• W2902515016 cites W2551630473 @default.
• W2902515016 cites W2585517132 @default.
• W2902515016 cites W2601498905 @default.
• W2902515016 cites W2607143962 @default.
• W2902515016 cites W2758825393 @default.
• W2902515016 cites W2766600534 @default.
• W2902515016 cites W2767225644 @default.
• W2902515016 cites W2768751537 @default.
• W2902515016 cites W2787463271 @default.
• W2902515016 cites W2793259288 @default.
• W2902515016 cites W2804082930 @default.
• W2902515016 cites W3028553899 @default.
• W2902515016 cites W4238567307 @default.
• W2902515016 cites W90736706 @default.
• W2902515016 doi "https://doi.org/10.1038/s41467-018-07402-8" @default.
• W2902515016 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6283830" @default.
• W2902515016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30523261" @default.
• W2902515016 hasPublicationYear "2018" @default.

• next