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- W2902524545 abstract "BACE1 inhibition is hypothesized to be a potential disease-modifying treatment for Alzheimer’s Disease (AD). Multiple BACE1 inhibitors have progressed into clinical trials, but several have been terminated due to off-target side effects or lack of therapeutic efficacy, presumably due to targeting an AD population progressed too far into the disease. The need for a next generation of BACE1 inhibitors has led to the discovery of JNJ-50138803. The initial medicinal chemistry synthesis is presented, as well as the evolution to more scalable synthesis routes, incorporating multiple improvements. This has culminated into a synthesis route, proven suitable to prepare a multikilogram GMP batch." @default.
- W2902524545 created "2018-12-11" @default.
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- W2902524545 date "2018-01-01" @default.
- W2902524545 modified "2023-10-16" @default.
- W2902524545 title "Discovery and Chemical Development of JNJ-50138803, a Clinical Candidate BACE1 Inhibitor" @default.
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- W2902524545 doi "https://doi.org/10.1021/bk-2018-1307.ch004" @default.
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