Matches in SemOpenAlex for { <https://semopenalex.org/work/W2902555145> ?p ?o ?g. }
- W2902555145 endingPage "39" @default.
- W2902555145 startingPage "29" @default.
- W2902555145 abstract "Abstract The BATF3-dependent cDC1 lineage of conventional dendritic cells (cDC) is required for rejection of immunogenic sarcomas and for rejection of progressive sarcomas during checkpoint blockade therapy. One unique function of the cDC1 lineage is the efficient cross-presentation of tumor-derived neoantigens to CD8+ T cells, but it is not clear that this is the only unique function of cDC1 required for tumor rejection. We previously showed that BATF3 functions during cDC1 lineage commitment to maintain IRF8 expression in the specified cDC1 progenitor. However, since cDC1 progenitors do not develop into mature cDC1s in Batf3−/− mice, it is still unclear whether BATF3 has additional functions in mature cDC1 cells. A transgenic Irf8-Venus reporter allele increases IRF8 protein concentration sufficiently to allow autonomous cDC1 development in spleens of Batf3−/− mice. These restored Batf3−/− cDC1s are transcriptionally similar to control wild-type cDC1s but have reduced expression of a restricted set of cDC1-specific genes. Restored Batf3−/− cDC1s are able to cross-present cell-associated antigens both in vitro and in vivo. However, Batf3−/− cDC1 exhibit altered characteristics in vivo and are unable to mediate tumor rejection. These results show that BATF3, in addition to regulating Irf8 expression to stabilize cDC1 lineage commitment, also controls expression of a small set of genes required for cDC1-mediated tumor rejection. These BATF3-regulated genes may be useful targets in immunotherapies aimed at promoting tumor rejection." @default.
- W2902555145 created "2018-12-11" @default.
- W2902555145 creator A5011478547 @default.
- W2902555145 creator A5036089606 @default.
- W2902555145 creator A5040420168 @default.
- W2902555145 creator A5050091823 @default.
- W2902555145 creator A5084261083 @default.
- W2902555145 creator A5085864834 @default.
- W2902555145 creator A5090464003 @default.
- W2902555145 date "2019-01-01" @default.
- W2902555145 modified "2023-10-16" @default.
- W2902555145 title "<i>Batf3</i>-Dependent Genes Control Tumor Rejection Induced by Dendritic Cells Independently of Cross-Presentation" @default.
- W2902555145 cites W1534709281 @default.
- W2902555145 cites W1642873092 @default.
- W2902555145 cites W1742769645 @default.
- W2902555145 cites W1968458512 @default.
- W2902555145 cites W1976199086 @default.
- W2902555145 cites W1977099733 @default.
- W2902555145 cites W1980255014 @default.
- W2902555145 cites W2004232796 @default.
- W2902555145 cites W2020744692 @default.
- W2902555145 cites W2032818498 @default.
- W2902555145 cites W2036012609 @default.
- W2902555145 cites W2046505430 @default.
- W2902555145 cites W2047604395 @default.
- W2902555145 cites W2065593489 @default.
- W2902555145 cites W2066761700 @default.
- W2902555145 cites W2079018735 @default.
- W2902555145 cites W2083252909 @default.
- W2902555145 cites W2084899911 @default.
- W2902555145 cites W2087479588 @default.
- W2902555145 cites W2091191929 @default.
- W2902555145 cites W2098129004 @default.
- W2902555145 cites W2101541399 @default.
- W2902555145 cites W2108449579 @default.
- W2902555145 cites W2108765339 @default.
- W2902555145 cites W2109868881 @default.
- W2902555145 cites W2114675972 @default.
- W2902555145 cites W2116332985 @default.
- W2902555145 cites W2134007339 @default.
- W2902555145 cites W2143523733 @default.
- W2902555145 cites W2144691651 @default.
- W2902555145 cites W2145034432 @default.
- W2902555145 cites W2147132132 @default.
- W2902555145 cites W2164462649 @default.
- W2902555145 cites W2169324807 @default.
- W2902555145 cites W2169390260 @default.
- W2902555145 cites W2180091996 @default.
- W2902555145 cites W2238741732 @default.
- W2902555145 cites W2341604280 @default.
- W2902555145 cites W2341849390 @default.
- W2902555145 cites W2412261015 @default.
- W2902555145 cites W2461271870 @default.
- W2902555145 cites W2510595980 @default.
- W2902555145 cites W2558002947 @default.
- W2902555145 cites W2586317281 @default.
- W2902555145 cites W2787835497 @default.
- W2902555145 doi "https://doi.org/10.1158/2326-6066.cir-18-0138" @default.
- W2902555145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30482745" @default.
- W2902555145 hasPublicationYear "2019" @default.
- W2902555145 type Work @default.
- W2902555145 sameAs 2902555145 @default.
- W2902555145 citedByCount "41" @default.
- W2902555145 countsByYear W29025551452019 @default.
- W2902555145 countsByYear W29025551452020 @default.
- W2902555145 countsByYear W29025551452021 @default.
- W2902555145 countsByYear W29025551452022 @default.
- W2902555145 countsByYear W29025551452023 @default.
- W2902555145 crossrefType "journal-article" @default.
- W2902555145 hasAuthorship W2902555145A5011478547 @default.
- W2902555145 hasAuthorship W2902555145A5036089606 @default.
- W2902555145 hasAuthorship W2902555145A5040420168 @default.
- W2902555145 hasAuthorship W2902555145A5050091823 @default.
- W2902555145 hasAuthorship W2902555145A5084261083 @default.
- W2902555145 hasAuthorship W2902555145A5085864834 @default.
- W2902555145 hasAuthorship W2902555145A5090464003 @default.
- W2902555145 hasConcept C104317684 @default.
- W2902555145 hasConcept C117705580 @default.
- W2902555145 hasConcept C150194340 @default.
- W2902555145 hasConcept C203014093 @default.
- W2902555145 hasConcept C207001950 @default.
- W2902555145 hasConcept C2776090121 @default.
- W2902555145 hasConcept C2778973524 @default.
- W2902555145 hasConcept C502942594 @default.
- W2902555145 hasConcept C54355233 @default.
- W2902555145 hasConcept C83464605 @default.
- W2902555145 hasConcept C86803240 @default.
- W2902555145 hasConcept C8891405 @default.
- W2902555145 hasConcept C95444343 @default.
- W2902555145 hasConceptScore W2902555145C104317684 @default.
- W2902555145 hasConceptScore W2902555145C117705580 @default.
- W2902555145 hasConceptScore W2902555145C150194340 @default.
- W2902555145 hasConceptScore W2902555145C203014093 @default.
- W2902555145 hasConceptScore W2902555145C207001950 @default.
- W2902555145 hasConceptScore W2902555145C2776090121 @default.
- W2902555145 hasConceptScore W2902555145C2778973524 @default.
- W2902555145 hasConceptScore W2902555145C502942594 @default.
- W2902555145 hasConceptScore W2902555145C54355233 @default.