Matches in SemOpenAlex for { <https://semopenalex.org/work/W2902568345> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2902568345 endingPage "3075" @default.
- W2902568345 startingPage "3075" @default.
- W2902568345 abstract "With the increasing antibiotic resistance of bacterial strains, alternative methods for infection control are in high demand. Quorum sensing (QS) is the bacterial communication system based on small molecules. QS is enables bacterial biofilm formation and pathogenic development. The interruption of QS has become a target for drug discovery, but remains in the early experimental phase. In this study, we synthesized a set of six compounds based on a scaffold (alkyl-quinoxalin-2(1H)-one), new in the anti-QS of Gram-negative bacteria Aeromonas caviae Sch3. By quantifying biofilm formation, we were able to monitor the effect of these compounds from concentrations of 1 to 100 µM. Significant reduction in biofilm formation was achieved by 3-hexylylquinoxalin-2(1H)-one (11), 3-hexylylquinoxalin-2(1H)-one-6-carboxylic acid (12), and 3-heptylylquinoxalin-2(1H)-one-6-carboxylic acid (14), ranging from 11% to 59% inhibition of the biofilm. This pilot study contributes to the development of anti-QS compounds to overcome the clinical challenge of resistant bacteria strains." @default.
- W2902568345 created "2018-12-11" @default.
- W2902568345 creator A5001800578 @default.
- W2902568345 creator A5005256336 @default.
- W2902568345 creator A5005833861 @default.
- W2902568345 creator A5008261322 @default.
- W2902568345 creator A5014024839 @default.
- W2902568345 date "2018-11-24" @default.
- W2902568345 modified "2023-09-30" @default.
- W2902568345 title "Design, Synthesis, and Evaluation of Alkyl-Quinoxalin-2(1H)-One Derivatives as Anti-Quorum Sensing Molecules, Inhibiting Biofilm Formation in Aeromonas caviae Sch3" @default.
- W2902568345 cites W1963733170 @default.
- W2902568345 cites W1978738358 @default.
- W2902568345 cites W1985255971 @default.
- W2902568345 cites W1987516720 @default.
- W2902568345 cites W2002317558 @default.
- W2902568345 cites W2013701719 @default.
- W2902568345 cites W2020292713 @default.
- W2902568345 cites W2040697076 @default.
- W2902568345 cites W2055364097 @default.
- W2902568345 cites W2059108829 @default.
- W2902568345 cites W2076026970 @default.
- W2902568345 cites W2076034198 @default.
- W2902568345 cites W2080246535 @default.
- W2902568345 cites W2087777043 @default.
- W2902568345 cites W2091989220 @default.
- W2902568345 cites W2098894017 @default.
- W2902568345 cites W2108808146 @default.
- W2902568345 cites W2131727615 @default.
- W2902568345 cites W2150967287 @default.
- W2902568345 cites W2321995885 @default.
- W2902568345 cites W2579294941 @default.
- W2902568345 doi "https://doi.org/10.3390/molecules23123075" @default.
- W2902568345 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6321446" @default.
- W2902568345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30477243" @default.
- W2902568345 hasPublicationYear "2018" @default.
- W2902568345 type Work @default.
- W2902568345 sameAs 2902568345 @default.
- W2902568345 citedByCount "13" @default.
- W2902568345 countsByYear W29025683452020 @default.
- W2902568345 countsByYear W29025683452021 @default.
- W2902568345 countsByYear W29025683452022 @default.
- W2902568345 countsByYear W29025683452023 @default.
- W2902568345 crossrefType "journal-article" @default.
- W2902568345 hasAuthorship W2902568345A5001800578 @default.
- W2902568345 hasAuthorship W2902568345A5005256336 @default.
- W2902568345 hasAuthorship W2902568345A5005833861 @default.
- W2902568345 hasAuthorship W2902568345A5008261322 @default.
- W2902568345 hasAuthorship W2902568345A5014024839 @default.
- W2902568345 hasBestOaLocation W29025683451 @default.
- W2902568345 hasConcept C118687296 @default.
- W2902568345 hasConcept C185592680 @default.
- W2902568345 hasConcept C21951064 @default.
- W2902568345 hasConcept C2777935563 @default.
- W2902568345 hasConcept C2780313371 @default.
- W2902568345 hasConcept C523546767 @default.
- W2902568345 hasConcept C54355233 @default.
- W2902568345 hasConcept C58123911 @default.
- W2902568345 hasConcept C86803240 @default.
- W2902568345 hasConcept C89423630 @default.
- W2902568345 hasConceptScore W2902568345C118687296 @default.
- W2902568345 hasConceptScore W2902568345C185592680 @default.
- W2902568345 hasConceptScore W2902568345C21951064 @default.
- W2902568345 hasConceptScore W2902568345C2777935563 @default.
- W2902568345 hasConceptScore W2902568345C2780313371 @default.
- W2902568345 hasConceptScore W2902568345C523546767 @default.
- W2902568345 hasConceptScore W2902568345C54355233 @default.
- W2902568345 hasConceptScore W2902568345C58123911 @default.
- W2902568345 hasConceptScore W2902568345C86803240 @default.
- W2902568345 hasConceptScore W2902568345C89423630 @default.
- W2902568345 hasFunder F4320324217 @default.
- W2902568345 hasFunder F4320324348 @default.
- W2902568345 hasIssue "12" @default.
- W2902568345 hasLocation W29025683451 @default.
- W2902568345 hasLocation W29025683452 @default.
- W2902568345 hasLocation W29025683453 @default.
- W2902568345 hasLocation W29025683454 @default.
- W2902568345 hasOpenAccess W2902568345 @default.
- W2902568345 hasPrimaryLocation W29025683451 @default.
- W2902568345 hasRelatedWork W1991292439 @default.
- W2902568345 hasRelatedWork W1994937222 @default.
- W2902568345 hasRelatedWork W2022515934 @default.
- W2902568345 hasRelatedWork W2052037206 @default.
- W2902568345 hasRelatedWork W2129197708 @default.
- W2902568345 hasRelatedWork W2161263829 @default.
- W2902568345 hasRelatedWork W2197362931 @default.
- W2902568345 hasRelatedWork W2264800049 @default.
- W2902568345 hasRelatedWork W2902568345 @default.
- W2902568345 hasRelatedWork W4206567109 @default.
- W2902568345 hasVolume "23" @default.
- W2902568345 isParatext "false" @default.
- W2902568345 isRetracted "false" @default.
- W2902568345 magId "2902568345" @default.
- W2902568345 workType "article" @default.