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- W2902570741 abstract "Alboflavusins (AFNs) are a group of cyclohexapeptides with moderate antibacterial and antitumor activities from Streptomyces alboflavus sp. 313. In vivo and in vitro studies proposed that AFNs are biosynthesized by a nonribosomal peptide synthetase machinery, and the 6-Cl-L-Trp precursor is supplied by a tryptophan halogenase gene located outside the afn gene cluster. Guided by the structure–activity relationship knowledge about the AFN-like cyclohexapeptides, two dimeric AFNs (di-AFNs) with regiospecific biaryl linkages were designed and generated biotechnologically by expressing the P450 gene hmtS or clpS in S. alboflavus wild-type and mutant strains. The di-AFNs displayed much better antibacterial and antitumor activities than their monomers as anticipated, exemplifying a rational strategy to generate natural product congeners with improved bioactivities." @default.
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- W2902570741 date "2018-12-05" @default.
- W2902570741 modified "2023-09-26" @default.
- W2902570741 title "Design and Biosynthesis of Dimeric Alboflavusins with Biaryl Linkages via Regiospecific C–C Bond Coupling" @default.
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- W2902570741 doi "https://doi.org/10.1021/jacs.8b10136" @default.
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