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- W2902590250 abstract "POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes) is a rare paraneoplastic syndrome, caused by a plasma cell proliferative disorder, which is most commonly lambda restricted. The neurological hallmark, which forms one of the mandatory criteria for diagnosis, is a subacute onset demyelinating neuropathy, which can be rapidly disabling and painful. A number of multi-system features are also characteristic of this disorder, and certainly not restricted to those included in its acronym, which though limited, remains a useful and memorable name, helping distinguish POEMS syndrome from other paraproteinaemic neuropathies. The discovery of vascular endothelial growth factor (VEGF) in association with POEMS syndrome has been extremely useful in aiding clinical diagnosis, and monitoring response to treatment, as well as helping understand the underlying mechanism of disease. Interestingly, however, treatment targeting VEGF has been disappointing, suggesting other disease mechanisms or inflammatory processes are also important. Current understanding of the pathogenesis of POEMS syndrome is outlined in detail in the accompanying article by Cerri et al. Here, we review the clinical features of POEMS syndrome, differential diagnosis and available treatment options, based on current literature." @default.
- W2902590250 created "2018-12-11" @default.
- W2902590250 creator A5067098327 @default.
- W2902590250 creator A5074637295 @default.
- W2902590250 date "2018-11-29" @default.
- W2902590250 modified "2023-10-16" @default.
- W2902590250 title "POEMS syndrome: clinical update" @default.
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- W2902590250 doi "https://doi.org/10.1007/s00415-018-9110-6" @default.
- W2902590250 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6342878" @default.
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