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- W2902595742 endingPage "98" @default.
- W2902595742 startingPage "91" @default.
- W2902595742 abstract "Since androgen receptor (AR) signaling is critically required for the development of prostate cancer (PCa), targeting AR axis has been the standard treatment of choice for advanced and metastatic PCa. Unfortunately, although the tumor initially responds to the therapy, treatment resistance eventually develops and the disease will progress. It is therefore imperative to identify the mechanisms of therapeutic resistance and novel molecular targets that are independent of AR signaling. Recent advances in pathology, molecular biology, genetics and genomics research have revealed novel AR-independent pathways that contribute to PCa carcinogenesis and progression. They include neuroendocrine differentiation, cell metabolism, DNA damage repair pathways and immune-mediated mechanisms. The development of novel agents targeting the non-AR mechanisms holds great promise to treat PCa that does not respond to AR-targeted therapies." @default.
- W2902595742 created "2018-12-11" @default.
- W2902595742 creator A5008739061 @default.
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- W2902595742 creator A5083109046 @default.
- W2902595742 creator A5083417334 @default.
- W2902595742 creator A5089340334 @default.
- W2902595742 date "2019-01-01" @default.
- W2902595742 modified "2023-10-14" @default.
- W2902595742 title "Targeting androgen receptor-independent pathways in therapy-resistant prostate cancer" @default.
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- W2902595742 doi "https://doi.org/10.1016/j.ajur.2018.11.002" @default.