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- W2902673352 endingPage "467" @default.
- W2902673352 startingPage "467" @default.
- W2902673352 abstract "The ubiquitin-proteasome pathway (UPP) is the central protein degradation system in eukaryotic cells, playing a key role in homeostasis maintenance, through proteolysis of regulatory and misfolded (potentially harmful) proteins. As cancer cells produce proteins inducing cell proliferation and inhibiting cell death pathways, UPP inhibition has been exploited as an anticancer strategy to shift the balance between protein synthesis and degradation towards cell death. Over the last few years, marine invertebrates and microorganisms have shown to be an unexhaustive factory of secondary metabolites targeting the UPP. These chemically intriguing compounds can inspire clinical development of novel antitumor drugs to cope with the incessant outbreak of side effects and resistance mechanisms induced by currently approved proteasome inhibitors (e.g., bortezomib). In this review, we report about (a) the role of the UPP in anticancer therapy, (b) chemical and biological properties of UPP inhibitors from marine sources discovered in the last decade, (c) high-throughput screening techniques for mining natural UPP inhibitors in organic extracts. Moreover, we will tell about the fascinating story of salinosporamide A, the first marine natural product to access clinical trials as a proteasome inhibitor for cancer treatment." @default.
- W2902673352 created "2018-12-11" @default.
- W2902673352 creator A5031326564 @default.
- W2902673352 creator A5046309539 @default.
- W2902673352 creator A5049857312 @default.
- W2902673352 creator A5059726492 @default.
- W2902673352 creator A5060005797 @default.
- W2902673352 creator A5088863031 @default.
- W2902673352 date "2018-11-26" @default.
- W2902673352 modified "2023-10-18" @default.
- W2902673352 title "Clogging the Ubiquitin-Proteasome Machinery with Marine Natural Products: Last Decade Update" @default.
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