FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2902731652> ?p ?o ?g. }

• W2902731652 endingPage "693" @default.
• W2902731652 startingPage "676" @default.
• W2902731652 abstract "Abnormal alternative splicing (AS) caused by alterations to splicing factors contributes to tumor progression. Serine/arginine splicing factor 1 (SRSF1) has emerged as a key oncodriver in numerous solid tumors, leaving its roles and mechanisms largely obscure in glioma. Here, we demonstrate that SRSF1 is increased in glioma tissues and cell lines. Moreover, its expression was correlated positively with tumor grade and Ki-67 index, but inversely with patient survival. Using RNA-Seq, we comprehensively screened and identified multiple SRSF1-affected AS events. Motif analysis revealed a position-dependent modulation of AS by SRSF1 in glioma. Functionally, we verified that SRSF1 promoted cell proliferation, survival, and invasion by specifically switching the AS of the myosin IB (MYO1B) gene and facilitating the expression of the oncogenic and membrane-localized isoform, MYO1B-fl. Strikingly, MYO1B splicing was dysregulated in parallel with SRSF1 expression in gliomas and predicted the poor prognosis of the patients. Further investigation revealed that SRSF1-guided AS of the MYO1B gene increased the tumorigenic potential of glioma cells through the PDK1/AKT and PAK/LIMK pathways. Taken together, we identify SRSF1 as an important oncodriver that integrates AS control of MYO1B into promotion of gliomagenesis and represents a potential prognostic biomarker and target for glioma therapy." @default.
• W2902731652 created "2018-12-11" @default.
• W2902731652 creator A5007209836 @default.
• W2902731652 creator A5021380919 @default.
• W2902731652 creator A5022860578 @default.
• W2902731652 creator A5036339709 @default.
• W2902731652 creator A5043104044 @default.
• W2902731652 creator A5046225712 @default.
• W2902731652 creator A5050103020 @default.
• W2902731652 creator A5056606390 @default.
• W2902731652 creator A5059109520 @default.
• W2902731652 creator A5063293101 @default.
• W2902731652 creator A5069948992 @default.
• W2902731652 creator A5070806671 @default.
• W2902731652 creator A5082950148 @default.
• W2902731652 date "2019-01-14" @default.
• W2902731652 modified "2023-10-13" @default.
• W2902731652 title "Splicing factor SRSF1 promotes gliomagenesis via oncogenic splice-switching of MYO1B" @default.
• W2902731652 cites W1825871834 @default.
• W2902731652 cites W1829675031 @default.
• W2902731652 cites W1880022530 @default.
• W2902731652 cites W1907787906 @default.
• W2902731652 cites W1970108031 @default.
• W2902731652 cites W1974765309 @default.
• W2902731652 cites W1983573091 @default.
• W2902731652 cites W1990323783 @default.
• W2902731652 cites W1990792484 @default.
• W2902731652 cites W1999060313 @default.
• W2902731652 cites W2003605043 @default.
• W2902731652 cites W2009258895 @default.
• W2902731652 cites W2010852376 @default.
• W2902731652 cites W2013940103 @default.
• W2902731652 cites W2019226300 @default.
• W2902731652 cites W2026657651 @default.
• W2902731652 cites W2026923004 @default.
• W2902731652 cites W2047769211 @default.
• W2902731652 cites W2058316685 @default.
• W2902731652 cites W2070732456 @default.
• W2902731652 cites W2071714380 @default.
• W2902731652 cites W2095998476 @default.
• W2902731652 cites W2096287682 @default.
• W2902731652 cites W2097257853 @default.
• W2902731652 cites W2098341282 @default.
• W2902731652 cites W2113623044 @default.
• W2902731652 cites W2114048083 @default.
• W2902731652 cites W2132923514 @default.
• W2902731652 cites W2133615225 @default.
• W2902731652 cites W2138431129 @default.
• W2902731652 cites W2156880617 @default.
• W2902731652 cites W2157936723 @default.
• W2902731652 cites W2165090547 @default.
• W2902731652 cites W2170774533 @default.
• W2902731652 cites W2188202548 @default.
• W2902731652 cites W2342358015 @default.
• W2902731652 cites W2366536035 @default.
• W2902731652 cites W2409027071 @default.
• W2902731652 cites W2516941822 @default.
• W2902731652 cites W2577586309 @default.
• W2902731652 cites W2585372137 @default.
• W2902731652 cites W2598705813 @default.
• W2902731652 cites W2742175163 @default.
• W2902731652 cites W2758602390 @default.
• W2902731652 doi "https://doi.org/10.1172/jci120279" @default.
• W2902731652 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6355305" @default.
• W2902731652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30481162" @default.
• W2902731652 hasPublicationYear "2019" @default.
• W2902731652 type Work @default.
• W2902731652 sameAs 2902731652 @default.
• W2902731652 citedByCount "93" @default.
• W2902731652 countsByYear W29027316522019 @default.
• W2902731652 countsByYear W29027316522020 @default.
• W2902731652 countsByYear W29027316522021 @default.
• W2902731652 countsByYear W29027316522022 @default.
• W2902731652 countsByYear W29027316522023 @default.
• W2902731652 crossrefType "journal-article" @default.
• W2902731652 hasAuthorship W2902731652A5007209836 @default.
• W2902731652 hasAuthorship W2902731652A5021380919 @default.
• W2902731652 hasAuthorship W2902731652A5022860578 @default.
• W2902731652 hasAuthorship W2902731652A5036339709 @default.
• W2902731652 hasAuthorship W2902731652A5043104044 @default.
• W2902731652 hasAuthorship W2902731652A5046225712 @default.
• W2902731652 hasAuthorship W2902731652A5050103020 @default.
• W2902731652 hasAuthorship W2902731652A5056606390 @default.
• W2902731652 hasAuthorship W2902731652A5059109520 @default.
• W2902731652 hasAuthorship W2902731652A5063293101 @default.
• W2902731652 hasAuthorship W2902731652A5069948992 @default.
• W2902731652 hasAuthorship W2902731652A5070806671 @default.
• W2902731652 hasAuthorship W2902731652A5082950148 @default.
• W2902731652 hasBestOaLocation W29027316521 @default.
• W2902731652 hasConcept C104317684 @default.
• W2902731652 hasConcept C10447831 @default.
• W2902731652 hasConcept C194583182 @default.
• W2902731652 hasConcept C2778227246 @default.
• W2902731652 hasConcept C502942594 @default.
• W2902731652 hasConcept C53345823 @default.
• W2902731652 hasConcept C54355233 @default.
• W2902731652 hasConcept C54458228 @default.
• W2902731652 hasConcept C62478195 @default.

• next