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• W2902762904 startingPage "86" @default.
• W2902762904 abstract "In this work, we report the design and fabrication of a dual-function integrated system to monitor, in real time, the release of previously loaded 2-methyl-1,4-naphthoquinone (MeNQ), also named vitamin K3. The newly developed system consists of poly(3,4-ethylenedioxythiophene) (PEDOT) nanoparticles, which were embedded into a poly-γ-glutamic acid (γ-PGA) biohydrogel during the gelling reaction between the biopolymer chains and the cross-linker, cystamine. After this, agglomerates of PEDOT nanoparticles homogeneously dispersed inside the biohydrogel were used as polymerization nuclei for the in situ anodic synthesis of poly(hydroxymethyl-3,4-ethylenedioxythiophene) in aqueous solution. After characterization of the resulting flexible electrode composites, their ability to load and release MeNQ was proven and monitored. Specifically, loaded MeNQ molecules, which organized in shells around PEDOT nanoparticles agglomerates when the drug was simply added to the initial gelling solution, were progressively released to a physiological medium. The latter process was successfully monitored using an electrode composite through differential pulse voltammetry. The fabrication of electroactive flexible biohydrogels for real-time release monitoring opens new opportunities for theranostic therapeutic approaches." @default.
• W2902762904 created "2018-12-11" @default.
• W2902762904 creator A5033713946 @default.
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• W2902762904 date "2018-11-28" @default.
• W2902762904 modified "2023-09-28" @default.
• W2902762904 title "Assembly of Conducting Polymer and Biohydrogel for the Release and Real-Time Monitoring of Vitamin K3" @default.
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• W2902762904 doi "https://doi.org/10.3390/gels4040086" @default.
• W2902762904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6318643" @default.
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• W2902762904 hasPublicationYear "2018" @default.
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