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- W2902776587 abstract "Breast cancer (BC) is the leading cause of cancer death in women worldwide due to the complicated etiology involving both genetic and environmental factors. Objective: To study the expression levels of miRNAs (-21, -221, -222, -429) in lymph in Wistar female rats in chemically induced breast cancer, resection and chemotherapy of breast cancer. Methods-The histological type of BC, the phenotype of BC cells, the level of mIRNAs expression in lymph was studied. Results-MNU-induced breast cancer in animal has ER-/PG+/Her2/neu- phenotype and therefore has common feature with human luminal A subtype of breast cancer. In the breast cancer group, lymphomas significantly increased the levels of miRNA-21 and miRNA-221 expression compared to the control group. After chemotherapy, the expression levels of miRNA-21 and miRNA-221 were significantly reduced compared to the BC group. In the BC group, the expression levels of miRNA-429 are significantly reduced compared to the control group. After chemotherapy, the expression of miRNA-429 is significantly increased in comparison with the BC group. Conclusion-In lymph miRNA-21 and miRNA-221 are diagnostic-relevant tumor markers. MicroRNA-429 is diagnostic-relevant marker of the chemotherapy effectiveness." @default.
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- W2902776587 date "2018-08-01" @default.
- W2902776587 modified "2023-09-26" @default.
- W2902776587 title "MicroRNA in Lymph in Experimental Breast Cancer" @default.
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- W2902776587 doi "https://doi.org/10.1109/csgb.2018.8544812" @default.
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