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- W2902806139 abstract "The association between obesity and survival in non-Hodgkin lymphoma is unclear. Using the Ontario Cancer Registry we conducted a retrospective analysis of incident cases of aggressive-histology B-cell lymphoma treated with a rituximab-containing regimen with curative intent between 2008–2016. 6246 patients were included. On multivariable analysis the rate of all-cause mortality was lower for the overweight body mass index (BMI 25–29.9 kg/m2) (HR 0.85; 95%CI 0.77–0.95) and obese BMI (≥30 kg/m2) (HR 0.75; 95%CI 0.67–0.85) groups compared to the normal weight group (18.5–24.9 kg/m2). Binomial logistic regression analysis revealed a lower odds ratio (OR) of admission to hospital during treatment in the overweight (OR 0.84; 95%CI 0.75–0.95) compared to normal weight BMI group. In the largest cohort to date of aggressive-histology B-cell lymphoma patients treated with rituximab, increased BMI is associated with a survival advantage, and the magnitude of this effect increases from overweight to obese BMI." @default.
- W2902806139 created "2018-12-11" @default.
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- W2902806139 date "2018-12-05" @default.
- W2902806139 modified "2023-09-25" @default.
- W2902806139 title "Improved survival in overweight and obese patients with aggressive B-cell lymphoma treated with rituximab-containing chemotherapy for curative intent" @default.
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- W2902806139 doi "https://doi.org/10.1080/10428194.2018.1538509" @default.
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