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• W2902808520 abstract "Aims To identify early clinical factors predictive of later morbidity in major depressive disorder (MDD). Methods We analysed factors associated with long‐term depressive morbidity (%‐time ill) between a first‐lifetime major depressive episode and last follow‐up of 116 adults diagnosed with DSM‐IV major depressive disorder. Bivariate comparisons were followed by multivariable linear regression modelling. Results Three factors were independently associated with an average of 25%‐time‐depressed over 17 years at risk: (a) agitated‐mixed, or psychotic features in initial major depressive episodes, (b) anxiety syndromes prior to a first‐lifetime major depressive episode, and (c) anxiety symptoms in childhood. Conclusion Early anxiety symptoms and syndromes and agitated‐mixed or psychotic initial depressive episodes predicted more long‐term depressive morbidity in MDD." @default.
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• W2902808520 date "2018-12-03" @default.
• W2902808520 modified "2023-10-16" @default.
• W2902808520 title "Early clinical predictors of long-term morbidity in major depressive disorder" @default.
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• W2902808520 doi "https://doi.org/10.1111/eip.12768" @default.
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