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- W2902900552 abstract "The design of a gene delivery system requires a complete understanding of the interaction between targeting cell and delivery systems. The poly(cystaminebis- (acrylamide)-diaminohexane) (poly(CBA-DAH)) has been confirmed as a bio-reducible efficient delivery carrier among the various systems. Poly(ethylenimine) (PEI, 1.8?kDa) was conjugated to poly(CBA-DAH) via a disulfide bond. The PEI conjugated poly(CBA-DAH) (PCDP) was able to bind with pDNA at a very low molecular weight ratio and form the polyplexes with nano-size and positive surface charge. To confirm the transfection efficiency, the plasmid DNA encodes with the luciferase reporter gene and green fluorescent protein reporter gene have made to use a bio-reducible efficient gene delivery. The PCDP polyplexes show 10 times higher gene transfection efficiency than Lipofectamine® polyplexes in bio-mimic in vivo condition. It has been reviewed that the bio-reducible PEI(1.8kDa) conjugated poly(CBA-DAH) is finally concluded as an efficient gene delivery carrier." @default.
- W2902900552 created "2018-12-11" @default.
- W2902900552 creator A5069167592 @default.
- W2902900552 date "2018-09-01" @default.
- W2902900552 modified "2023-09-28" @default.
- W2902900552 title "Recent Development of Bio-Reducible Polymers for Efficient Gene Delivery System" @default.
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- W2902900552 doi "https://doi.org/10.29245/2578-2967/2018/5.1145" @default.
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