FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2902938370> ?p ?o ?g. }

• W2902938370 endingPage "62" @default.
• W2902938370 startingPage "57" @default.
• W2902938370 abstract "Vertebrates release glucocorticoids during stressful events. If stress occurs during reproduction, the resulting offspring can show altered phenotypes that are thought to arise from increased exposure to maternal glucocorticoids. Developing offspring can metabolize maternal glucocorticoids, which can alter the pattern of exposure they encounter. For egg laying vertebrates, we are just beginning to understand how embryonic steroid metabolism impacts embryonic exposure to maternal glucocorticoids. Here we injected three doses of radioactive corticosterone into Japanese quail (Coturnix japonica) eggs to determine the degree of embryonic exposure at days six and nine of development. We found that increasing injection dose increased the amount of radioactivity found in the embryo at day six but by day nine the effect of injection dose disappeared as the amount of radioactivity within the embryo dropped to equivalent levels for all three doses. Interestingly, when examined as a percentage of initial dose, there were no differences between treatment groups at any time points. Importantly, using thin-layer chromatography we characterized that some free steroid, putatively identified as corticosterone, does reach the developing embryo. Together, our data suggest that the in ovo metabolism of maternal corticosterone can eventually eliminate it from the egg, but before this happens, embryos developing in eggs with elevated amounts of maternal corticosterone are exposed to higher levels early in development. This has important implications for how we understand the developmental steroid environment and the mechanisms underlying maternal stress effects." @default.
• W2902938370 created "2018-12-11" @default.
• W2902938370 creator A5013092294 @default.
• W2902938370 creator A5025114350 @default.
• W2902938370 creator A5027713514 @default.
• W2902938370 creator A5032630425 @default.
• W2902938370 date "2019-02-01" @default.
• W2902938370 modified "2023-10-15" @default.
• W2902938370 title "In ovo metabolism and yolk glucocorticoid concentration interact to influence embryonic glucocorticoid exposure patterns" @default.
• W2902938370 cites W1968311059 @default.
• W2902938370 cites W1968311559 @default.
• W2902938370 cites W1981748148 @default.
• W2902938370 cites W1994919529 @default.
• W2902938370 cites W1997923859 @default.
• W2902938370 cites W2011718521 @default.
• W2902938370 cites W2014668126 @default.
• W2902938370 cites W2019314939 @default.
• W2902938370 cites W2024235957 @default.
• W2902938370 cites W2024793161 @default.
• W2902938370 cites W2033782359 @default.
• W2902938370 cites W2045723497 @default.
• W2902938370 cites W2046256178 @default.
• W2902938370 cites W2054397935 @default.
• W2902938370 cites W2080442882 @default.
• W2902938370 cites W2081891489 @default.
• W2902938370 cites W2083498589 @default.
• W2902938370 cites W2095454140 @default.
• W2902938370 cites W2096973259 @default.
• W2902938370 cites W2100750211 @default.
• W2902938370 cites W2102185269 @default.
• W2902938370 cites W2103691504 @default.
• W2902938370 cites W2105643302 @default.
• W2902938370 cites W2112204642 @default.
• W2902938370 cites W2132539548 @default.
• W2902938370 cites W2133152044 @default.
• W2902938370 cites W2136128738 @default.
• W2902938370 cites W2148650828 @default.
• W2902938370 cites W2149981189 @default.
• W2902938370 cites W2167203688 @default.
• W2902938370 cites W2169477195 @default.
• W2902938370 cites W2883372221 @default.
• W2902938370 cites W2885171560 @default.
• W2902938370 doi "https://doi.org/10.1016/j.ygcen.2018.11.013" @default.
• W2902938370 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7480747" @default.
• W2902938370 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30500372" @default.
• W2902938370 hasPublicationYear "2019" @default.
• W2902938370 type Work @default.
• W2902938370 sameAs 2902938370 @default.
• W2902938370 citedByCount "15" @default.
• W2902938370 countsByYear W29029383702019 @default.
• W2902938370 countsByYear W29029383702020 @default.
• W2902938370 countsByYear W29029383702021 @default.
• W2902938370 countsByYear W29029383702023 @default.
• W2902938370 crossrefType "journal-article" @default.
• W2902938370 hasAuthorship W2902938370A5013092294 @default.
• W2902938370 hasAuthorship W2902938370A5025114350 @default.
• W2902938370 hasAuthorship W2902938370A5027713514 @default.
• W2902938370 hasAuthorship W2902938370A5032630425 @default.
• W2902938370 hasBestOaLocation W29029383702 @default.
• W2902938370 hasConcept C112672928 @default.
• W2902938370 hasConcept C126322002 @default.
• W2902938370 hasConcept C134018914 @default.
• W2902938370 hasConcept C16685009 @default.
• W2902938370 hasConcept C180838311 @default.
• W2902938370 hasConcept C18903297 @default.
• W2902938370 hasConcept C196843134 @default.
• W2902938370 hasConcept C2777043721 @default.
• W2902938370 hasConcept C2777882087 @default.
• W2902938370 hasConcept C2778303931 @default.
• W2902938370 hasConcept C2778765379 @default.
• W2902938370 hasConcept C2779234561 @default.
• W2902938370 hasConcept C2780352252 @default.
• W2902938370 hasConcept C2780841215 @default.
• W2902938370 hasConcept C2781321622 @default.
• W2902938370 hasConcept C54355233 @default.
• W2902938370 hasConcept C62231903 @default.
• W2902938370 hasConcept C71315377 @default.
• W2902938370 hasConcept C71924100 @default.
• W2902938370 hasConcept C86803240 @default.
• W2902938370 hasConcept C87073359 @default.
• W2902938370 hasConcept C95444343 @default.
• W2902938370 hasConceptScore W2902938370C112672928 @default.
• W2902938370 hasConceptScore W2902938370C126322002 @default.
• W2902938370 hasConceptScore W2902938370C134018914 @default.
• W2902938370 hasConceptScore W2902938370C16685009 @default.
• W2902938370 hasConceptScore W2902938370C180838311 @default.
• W2902938370 hasConceptScore W2902938370C18903297 @default.
• W2902938370 hasConceptScore W2902938370C196843134 @default.
• W2902938370 hasConceptScore W2902938370C2777043721 @default.
• W2902938370 hasConceptScore W2902938370C2777882087 @default.
• W2902938370 hasConceptScore W2902938370C2778303931 @default.
• W2902938370 hasConceptScore W2902938370C2778765379 @default.
• W2902938370 hasConceptScore W2902938370C2779234561 @default.
• W2902938370 hasConceptScore W2902938370C2780352252 @default.
• W2902938370 hasConceptScore W2902938370C2780841215 @default.
• W2902938370 hasConceptScore W2902938370C2781321622 @default.
• W2902938370 hasConceptScore W2902938370C54355233 @default.
• W2902938370 hasConceptScore W2902938370C62231903 @default.

• next