FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2902949761> ?p ?o ?g. }

• W2902949761 abstract "Background/Objective: Perinatal hypoxic-ischemia (HI) causes neonatal death and permanent neurological deficits. Cell therapy using various cell sources has been recently identified as a novel therapy for perinatal HI. Among the available types of cell sources, bone marrow-derived mononuclear cells (BMMNCs) have unique features for clinical application. For example, stem cells can be collected after admission, thus enabling us to perform autologous transplantation. This study aimed to investigate whether the administration of BMMNCs ameliorated HI brain injury in a neonatal rat model. Methods: Seven-day-old rats underwent left carotid artery ligation and were exposed to 8% oxygen for 60 min. BMMNCs were collected from the femurs and tibias of juvenile rats using the Ficoll-Hypaque technique and injected intravenously 24 h after the insult (1 × 105 cells). Active caspase-3, as an apoptosis marker, and ED1, as an activated microglia/macrophage marker, were evaluated immunohistochemically 48 h after the insult (vehicle, n = 9; BMMNC, n = 10). Behavioral assessments using the rotarod treadmill, gait analysis, and active avoidance tests were initiated 3 weeks after the insult (sham, n = 9, vehicle, n = 8; BMMNC, n = 8). After these behavioral tests (6 weeks after the insult), we evaluated the volumes of their hippocampi, cortices, thalami, striata, and globus pallidus. Results: The mean cell densities of the sum of four parts that were positive for active caspase-3 significantly decreased in the BMMNC group (p < 0.05), whereas in the hippocampi, cortices, thalami, and striata cell densities decreased by 42, 60, 56, and 47%, respectively, although statistical significance was not attained. The number of ED1 positive cells for the sum of the four parts also significantly decreased in the BMMNC group compared to the vehicle group (p < 0.05), whereas in each of the four parts the decrease was 35, 39, 47, and 36%, respectively, although statistical significance was not attained. In gait analysis, the BMMNC normalized the contact area of the affected hind paw widened by HI. The volumes of the affected striata and globus pallidus were significantly larger in the BMMNC group than in the control group. Conclusion: These results indicated that the injection of BMMNCs ameliorated HI brain injury in a neonatal rat model." @default.
• W2902949761 created "2018-12-11" @default.
• W2902949761 creator A5007671862 @default.
• W2902949761 creator A5010151154 @default.
• W2902949761 creator A5019154340 @default.
• W2902949761 creator A5022561314 @default.
• W2902949761 creator A5027510626 @default.
• W2902949761 creator A5029919797 @default.
• W2902949761 creator A5050506759 @default.
• W2902949761 creator A5062202519 @default.
• W2902949761 creator A5065887873 @default.
• W2902949761 creator A5067454062 @default.
• W2902949761 creator A5070060856 @default.
• W2902949761 creator A5073243799 @default.
• W2902949761 creator A5088767188 @default.
• W2902949761 date "2018-11-30" @default.
• W2902949761 modified "2023-10-03" @default.
• W2902949761 title "Administration of Bone Marrow-Derived Mononuclear Cells Contributed to the Reduction of Hypoxic-Ischemic Brain Injury in Neonatal Rats" @default.
• W2902949761 cites W1873377305 @default.
• W2902949761 cites W1965953554 @default.
• W2902949761 cites W1967315370 @default.
• W2902949761 cites W1967537556 @default.
• W2902949761 cites W1970895440 @default.
• W2902949761 cites W1980701138 @default.
• W2902949761 cites W1986577473 @default.
• W2902949761 cites W1989820252 @default.
• W2902949761 cites W1991055478 @default.
• W2902949761 cites W1993845966 @default.
• W2902949761 cites W2009285092 @default.
• W2902949761 cites W2013735929 @default.
• W2902949761 cites W2014546912 @default.
• W2902949761 cites W2019091990 @default.
• W2902949761 cites W2027657767 @default.
• W2902949761 cites W2028029480 @default.
• W2902949761 cites W2034093030 @default.
• W2902949761 cites W2036978268 @default.
• W2902949761 cites W2043876120 @default.
• W2902949761 cites W2044896636 @default.
• W2902949761 cites W2049465870 @default.
• W2902949761 cites W2052097860 @default.
• W2902949761 cites W2053900100 @default.
• W2902949761 cites W2054663153 @default.
• W2902949761 cites W2060887306 @default.
• W2902949761 cites W2062437158 @default.
• W2902949761 cites W2069357678 @default.
• W2902949761 cites W2070861049 @default.
• W2902949761 cites W2080206255 @default.
• W2902949761 cites W2086215394 @default.
• W2902949761 cites W2095735594 @default.
• W2902949761 cites W2107784279 @default.
• W2902949761 cites W2110525047 @default.
• W2902949761 cites W2112963538 @default.
• W2902949761 cites W2115299328 @default.
• W2902949761 cites W2135122869 @default.
• W2902949761 cites W2136967026 @default.
• W2902949761 cites W2162800365 @default.
• W2902949761 cites W2164127547 @default.
• W2902949761 cites W2169898931 @default.
• W2902949761 cites W2325707043 @default.
• W2902949761 cites W2356626107 @default.
• W2902949761 cites W2511190783 @default.
• W2902949761 cites W2593301937 @default.
• W2902949761 cites W2593657915 @default.
• W2902949761 cites W2607246646 @default.
• W2902949761 cites W2620241325 @default.
• W2902949761 cites W2792920542 @default.
• W2902949761 cites W2890360649 @default.
• W2902949761 cites W2891128101 @default.
• W2902949761 doi "https://doi.org/10.3389/fneur.2018.00987" @default.
• W2902949761 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6284369" @default.
• W2902949761 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30559704" @default.
• W2902949761 hasPublicationYear "2018" @default.
• W2902949761 type Work @default.
• W2902949761 sameAs 2902949761 @default.
• W2902949761 citedByCount "8" @default.
• W2902949761 countsByYear W29029497612020 @default.
• W2902949761 countsByYear W29029497612021 @default.
• W2902949761 countsByYear W29029497612022 @default.
• W2902949761 countsByYear W29029497612023 @default.
• W2902949761 crossrefType "journal-article" @default.
• W2902949761 hasAuthorship W2902949761A5007671862 @default.
• W2902949761 hasAuthorship W2902949761A5010151154 @default.
• W2902949761 hasAuthorship W2902949761A5019154340 @default.
• W2902949761 hasAuthorship W2902949761A5022561314 @default.
• W2902949761 hasAuthorship W2902949761A5027510626 @default.
• W2902949761 hasAuthorship W2902949761A5029919797 @default.
• W2902949761 hasAuthorship W2902949761A5050506759 @default.
• W2902949761 hasAuthorship W2902949761A5062202519 @default.
• W2902949761 hasAuthorship W2902949761A5065887873 @default.
• W2902949761 hasAuthorship W2902949761A5067454062 @default.
• W2902949761 hasAuthorship W2902949761A5070060856 @default.
• W2902949761 hasAuthorship W2902949761A5073243799 @default.
• W2902949761 hasAuthorship W2902949761A5088767188 @default.
• W2902949761 hasBestOaLocation W29029497611 @default.
• W2902949761 hasConcept C126322002 @default.
• W2902949761 hasConcept C137061746 @default.
• W2902949761 hasConcept C142724271 @default.
• W2902949761 hasConcept C202751555 @default.
• W2902949761 hasConcept C2776914184 @default.
• W2902949761 hasConcept C2779830541 @default.

• next