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• W2902956720 abstract "Abstract The tachykinin substance P (SP) increases neuronal excitability, participates in homeostatic control, but induces brain oedema after stroke or trauma. We asked whether SP is able to induce cortical spreading depression (CSD) which often aggravates stroke-induced pathology. In anesthetized rats we applied SP (10 −5 , 10 −6 , 10 −7 , or 10 −8 mol/L) to a restricted cortical area and recorded CSDs there and in remote non-treated areas using microelectrodes. SP was either applied in artificial cerebrospinal fluid (ACSF), or in aqua to perform a preconditioning. Plasma extravasation in cortical grey matter was assessed with Evans Blue. Only SP dissolved in aqua induced self-regenerating CSDs. SP dissolved in ACSF did not ignite CSDs even when excitability was increased by acetate-preconditioning. Aqua alone elicited as few CSDs as the lowest concentration of SP. Local pretreatment with 250 nmol/L of a neurokinin 1 receptor antagonist prevented the SP-induced plasma extravasation, the initiation of CSDs by 10 −5 mol/L SP diluted in aqua, and the initiation of CSDs by aqua alone, but did not suppress KCl-induced CSD. Thus neurokinin 1 receptor antagonists may be used to explore the involvement of SP in CSDs in clinical studies." @default.
• W2902956720 created "2018-12-11" @default.
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• W2902956720 date "2018-12-05" @default.
• W2902956720 modified "2023-10-12" @default.
• W2902956720 title "The potential of substance P to initiate and perpetuate cortical spreading depression (CSD) in rat in vivo" @default.
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• W2902956720 doi "https://doi.org/10.1038/s41598-018-36330-2" @default.
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