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• W2902972136 abstract "Abstract Maduramicin (Mad), a polyether ionophore antibiotic, has been reported to be toxic to animals and humans because of being used at high doses or for long time, resulting in heart failure. However, the toxic mechanism of Mad in cardiac muscle cells is not well understood. Here, we show that Mad induced cell viability reduction and apoptosis in cardiac‐derived H9c2, HL‐1 cells, primary cardiomyocytes, and murine cardiac muscles, which was because of the inhibition of extracellular‐signal‐regulated kinase 1/2 (Erk1/2). Expression of constitutively active mitogen‐activated protein kinase kinase 1 (MKK1) attenuated Mad‐induced cell death in H9c2 cells, whereas silencing Erk1/2 or ectopic expression of dominant negative MKK1 strengthened Mad‐induced cell death. Moreover, we found that both phosphatase and tensin homolog on chromosome 10 (PTEN) and protein kinase B (Akt) were implicated in the regulation of Erk1/2 inactivation and apoptosis in the cells and tissues exposed to Mad. Overexpression of dominant negative PTEN and/or constitutively active Akt, or constitutively active Akt and/or constitutively active MKK1 rescued the cells from Mad‐induced dephosphorylated‐Erk1/2 and cell death. Furthermore, Mad‐induced reactive oxygen species (ROS) activated PTEN and inactivated Akt–Erk1/2 contributing to cell death, as N‐acetyl‐ L ‐cysteine ameliorated the event. Taken together, the results disclose that Mad inhibits Erk1/2 via ROS‐dependent activation of PTEN and inactivation of Akt, leading to cell death in cardiac muscle cells. Our findings suggest that manipulation of the ROS–PTEN–Akt–Erk1/2 pathway may be a potential approach to prevent Mad‐induced cardiotoxicity." @default.
• W2902972136 created "2018-12-11" @default.
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• W2902972136 date "2018-12-03" @default.
• W2902972136 modified "2023-09-27" @default.
• W2902972136 title "Maduramicin induces cardiac muscle cell death by the ROS‐dependent PTEN/Akt–Erk1/2 signaling pathway" @default.
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• W2902972136 doi "https://doi.org/10.1002/jcp.27830" @default.
• W2902972136 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6426669" @default.
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