FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2902981276> ?p ?o ?g. }

• W2902981276 abstract "Artemisinin is well known for its irreplaceable curative effect on the devastating parasitic disease, Malaria. This sesquiterpenoid is specifically produced in Chinese traditional herbal plant Artemisia annua. Earlier studies show that phytohormone abscisic acid (ABA) plays an important role in improving the artemisinin content, but how ABA regulates artemisinin biosynthesis is still poorly understood. In this study, we identified AaABF3 encoding an ABRE (ABA-responsive elements) binding factors. QRT-PCR analysis showed that AaABF3 expressed much higher in trichomes where artemisinin synthesizes and accumulates, and induced by ABA. To further investigate the mechanism through which AaABF3 regulates artemisinin biosynthesis, we carried out dual-luciferase analysis and yeast one-hybrid assay, and the results revealed that AaABF3 could directly bind to the promoter of ALDH1 gene, which is a key regulator in artemisinin biosynthesis, and activate the expression of ALDH1. Function analysis revealed that overexpression of AaABF3 in A. annua enhanced the production of artemisinin, while RNA interference of AaABF3 resulted in decreased artemisinin content. Taken together, our results demonstrate that AaABF3 plays an important role in ABA-regulated artemisinin biosynthesis through direct regulation of artemisinin biosynthesis gene, ALDH1." @default.
• W2902981276 created "2018-12-11" @default.
• W2902981276 creator A5000877114 @default.
• W2902981276 creator A5039516755 @default.
• W2902981276 creator A5039664895 @default.
• W2902981276 creator A5041460413 @default.
• W2902981276 creator A5057923496 @default.
• W2902981276 creator A5059331736 @default.
• W2902981276 creator A5070394658 @default.
• W2902981276 creator A5081625901 @default.
• W2902981276 creator A5084672816 @default.
• W2902981276 creator A5091455657 @default.
• W2902981276 date "2018-11-28" @default.
• W2902981276 modified "2023-10-14" @default.
• W2902981276 title "AaABF3, an Abscisic Acid–Responsive Transcription Factor, Positively Regulates Artemisinin Biosynthesis in Artemisia annua" @default.
• W2902981276 cites W1493809802 @default.
• W2902981276 cites W1539503448 @default.
• W2902981276 cites W1571265670 @default.
• W2902981276 cites W1964082165 @default.
• W2902981276 cites W1967648518 @default.
• W2902981276 cites W1984824352 @default.
• W2902981276 cites W1990226486 @default.
• W2902981276 cites W1992362149 @default.
• W2902981276 cites W2019281554 @default.
• W2902981276 cites W2033803943 @default.
• W2902981276 cites W2033812623 @default.
• W2902981276 cites W2045115500 @default.
• W2902981276 cites W2052703668 @default.
• W2902981276 cites W2064909918 @default.
• W2902981276 cites W2080053579 @default.
• W2902981276 cites W2080641142 @default.
• W2902981276 cites W2084837508 @default.
• W2902981276 cites W2085027598 @default.
• W2902981276 cites W2092423868 @default.
• W2902981276 cites W2102499150 @default.
• W2902981276 cites W2129447528 @default.
• W2902981276 cites W2145808088 @default.
• W2902981276 cites W2149202606 @default.
• W2902981276 cites W2171731113 @default.
• W2902981276 cites W2274204875 @default.
• W2902981276 cites W2279195969 @default.
• W2902981276 cites W2468246338 @default.
• W2902981276 cites W2473639098 @default.
• W2902981276 cites W2559821950 @default.
• W2902981276 cites W2768973916 @default.
• W2902981276 cites W2781002513 @default.
• W2902981276 cites W2801929869 @default.
• W2902981276 cites W2883811707 @default.
• W2902981276 cites W4254196027 @default.
• W2902981276 doi "https://doi.org/10.3389/fpls.2018.01777" @default.
• W2902981276 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6279931" @default.
• W2902981276 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30546379" @default.
• W2902981276 hasPublicationYear "2018" @default.
• W2902981276 type Work @default.
• W2902981276 sameAs 2902981276 @default.
• W2902981276 citedByCount "15" @default.
• W2902981276 countsByYear W29029812762019 @default.
• W2902981276 countsByYear W29029812762020 @default.
• W2902981276 countsByYear W29029812762021 @default.
• W2902981276 countsByYear W29029812762022 @default.
• W2902981276 countsByYear W29029812762023 @default.
• W2902981276 crossrefType "journal-article" @default.
• W2902981276 hasAuthorship W2902981276A5000877114 @default.
• W2902981276 hasAuthorship W2902981276A5039516755 @default.
• W2902981276 hasAuthorship W2902981276A5039664895 @default.
• W2902981276 hasAuthorship W2902981276A5041460413 @default.
• W2902981276 hasAuthorship W2902981276A5057923496 @default.
• W2902981276 hasAuthorship W2902981276A5059331736 @default.
• W2902981276 hasAuthorship W2902981276A5070394658 @default.
• W2902981276 hasAuthorship W2902981276A5081625901 @default.
• W2902981276 hasAuthorship W2902981276A5084672816 @default.
• W2902981276 hasAuthorship W2902981276A5091455657 @default.
• W2902981276 hasBestOaLocation W29029812761 @default.
• W2902981276 hasConcept C104317684 @default.
• W2902981276 hasConcept C166703698 @default.
• W2902981276 hasConcept C203014093 @default.
• W2902981276 hasConcept C2776120307 @default.
• W2902981276 hasConcept C2778048844 @default.
• W2902981276 hasConcept C2778371730 @default.
• W2902981276 hasConcept C2779591172 @default.
• W2902981276 hasConcept C2779691961 @default.
• W2902981276 hasConcept C553450214 @default.
• W2902981276 hasConcept C55493867 @default.
• W2902981276 hasConcept C67705224 @default.
• W2902981276 hasConcept C86339819 @default.
• W2902981276 hasConcept C86803240 @default.
• W2902981276 hasConceptScore W2902981276C104317684 @default.
• W2902981276 hasConceptScore W2902981276C166703698 @default.
• W2902981276 hasConceptScore W2902981276C203014093 @default.
• W2902981276 hasConceptScore W2902981276C2776120307 @default.
• W2902981276 hasConceptScore W2902981276C2778048844 @default.
• W2902981276 hasConceptScore W2902981276C2778371730 @default.
• W2902981276 hasConceptScore W2902981276C2779591172 @default.
• W2902981276 hasConceptScore W2902981276C2779691961 @default.
• W2902981276 hasConceptScore W2902981276C553450214 @default.
• W2902981276 hasConceptScore W2902981276C55493867 @default.
• W2902981276 hasConceptScore W2902981276C67705224 @default.
• W2902981276 hasConceptScore W2902981276C86339819 @default.
• W2902981276 hasConceptScore W2902981276C86803240 @default.
• W2902981276 hasFunder F4320306137 @default.

• next