FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2902997102> ?p ?o ?g. }

• W2902997102 endingPage "60" @default.
• W2902997102 startingPage "51" @default.
• W2902997102 abstract "Supplemental O2 (hyperoxia; 30-90% O2) is a necessary intervention for premature infants, but it contributes to development of neonatal and pediatric asthma, necessitating better understanding of contributory mechanisms in hyperoxia-induced changes to airway structure and function. In adults, environmental stressors promote formation of senescent cells that secrete factors (senescence-associated secretory phenotype), which can be inflammatory and have paracrine effects that enhance chronic lung diseases. Hyperoxia-induced changes in airway structure and function are mediated in part by effects on airway smooth muscle (ASM). In the present study, using human fetal ASM cells as a model of prematurity, we ascertained the effects of clinically relevant moderate hyperoxia (40% O2) on cellular senescence. Fetal ASM exposed to 40% O2 for 7 days exhibited elevated concentrations of senescence-associated markers, including β-galactosidase; cell cycle checkpoint proteins p16, p21, and p-p53; and the DNA damage marker p-γH2A.X (phosphorylated γ-histone family member X). The combination of dasatinib and quercetin, compounds known to eliminate senescent cells (senolytics), reduced the number of hyperoxia-exposed β-galactosidase-, p21-, p16-, and p-γH2A.X-positive ASM cells. The senescence-associated secretory phenotype profile of hyperoxia-exposed cells included both profibrotic and proinflammatory mediators. Naive ASM exposed to media from hyperoxia-exposed senescent cells exhibited increased collagen and fibronectin and higher contractility. Our data show that induction of cellular senescence by hyperoxia leads to secretion of inflammatory factors and has a functional effect on naive ASM. Cellular senescence in the airway may thus contribute to pediatric airway disease in the context of sequelae of preterm birth." @default.
• W2902997102 created "2018-12-11" @default.
• W2902997102 creator A5009102749 @default.
• W2902997102 creator A5014342029 @default.
• W2902997102 creator A5024561708 @default.
• W2902997102 creator A5032830303 @default.
• W2902997102 creator A5035803024 @default.
• W2902997102 creator A5040325695 @default.
• W2902997102 creator A5045820799 @default.
• W2902997102 creator A5055605191 @default.
• W2902997102 creator A5059974064 @default.
• W2902997102 creator A5071610306 @default.
• W2902997102 creator A5078156204 @default.
• W2902997102 creator A5079580565 @default.
• W2902997102 creator A5080897076 @default.
• W2902997102 creator A5087480824 @default.
• W2902997102 date "2019-07-01" @default.
• W2902997102 modified "2023-10-12" @default.
• W2902997102 title "Hyperoxia-induced Cellular Senescence in Fetal Airway Smooth Muscle Cells" @default.
• W2902997102 cites W1528603119 @default.
• W2902997102 cites W1963983776 @default.
• W2902997102 cites W1967818318 @default.
• W2902997102 cites W1968417129 @default.
• W2902997102 cites W1982481909 @default.
• W2902997102 cites W2006905411 @default.
• W2902997102 cites W2024586859 @default.
• W2902997102 cites W2025283490 @default.
• W2902997102 cites W2031502025 @default.
• W2902997102 cites W2036950235 @default.
• W2902997102 cites W2039698012 @default.
• W2902997102 cites W2044529039 @default.
• W2902997102 cites W2047124316 @default.
• W2902997102 cites W2049691960 @default.
• W2902997102 cites W2083060807 @default.
• W2902997102 cites W2084158088 @default.
• W2902997102 cites W2096977033 @default.
• W2902997102 cites W2099540110 @default.
• W2902997102 cites W2107969572 @default.
• W2902997102 cites W2108887402 @default.
• W2902997102 cites W2120399491 @default.
• W2902997102 cites W2120736394 @default.
• W2902997102 cites W2128412773 @default.
• W2902997102 cites W2128807350 @default.
• W2902997102 cites W2145208343 @default.
• W2902997102 cites W2160310657 @default.
• W2902997102 cites W2167654458 @default.
• W2902997102 cites W2169986172 @default.
• W2902997102 cites W2193792657 @default.
• W2902997102 cites W2234014638 @default.
• W2902997102 cites W2266290735 @default.
• W2902997102 cites W2267655771 @default.
• W2902997102 cites W2312584566 @default.
• W2902997102 cites W2328126338 @default.
• W2902997102 cites W2415950024 @default.
• W2902997102 cites W2469481756 @default.
• W2902997102 cites W2497953377 @default.
• W2902997102 cites W2518394218 @default.
• W2902997102 cites W2550955456 @default.
• W2902997102 cites W2591114726 @default.
• W2902997102 cites W2591983504 @default.
• W2902997102 cites W2594519469 @default.
• W2902997102 cites W2605674430 @default.
• W2902997102 cites W2752668646 @default.
• W2902997102 cites W2766851995 @default.
• W2902997102 cites W812420069 @default.
• W2902997102 doi "https://doi.org/10.1165/rcmb.2018-0176oc" @default.
• W2902997102 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6604224" @default.
• W2902997102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30508396" @default.
• W2902997102 hasPublicationYear "2019" @default.
• W2902997102 type Work @default.
• W2902997102 sameAs 2902997102 @default.
• W2902997102 citedByCount "50" @default.
• W2902997102 countsByYear W29029971022019 @default.
• W2902997102 countsByYear W29029971022020 @default.
• W2902997102 countsByYear W29029971022021 @default.
• W2902997102 countsByYear W29029971022022 @default.
• W2902997102 countsByYear W29029971022023 @default.
• W2902997102 crossrefType "journal-article" @default.
• W2902997102 hasAuthorship W2902997102A5009102749 @default.
• W2902997102 hasAuthorship W2902997102A5014342029 @default.
• W2902997102 hasAuthorship W2902997102A5024561708 @default.
• W2902997102 hasAuthorship W2902997102A5032830303 @default.
• W2902997102 hasAuthorship W2902997102A5035803024 @default.
• W2902997102 hasAuthorship W2902997102A5040325695 @default.
• W2902997102 hasAuthorship W2902997102A5045820799 @default.
• W2902997102 hasAuthorship W2902997102A5055605191 @default.
• W2902997102 hasAuthorship W2902997102A5059974064 @default.
• W2902997102 hasAuthorship W2902997102A5071610306 @default.
• W2902997102 hasAuthorship W2902997102A5078156204 @default.
• W2902997102 hasAuthorship W2902997102A5079580565 @default.
• W2902997102 hasAuthorship W2902997102A5080897076 @default.
• W2902997102 hasAuthorship W2902997102A5087480824 @default.
• W2902997102 hasBestOaLocation W29029971022 @default.
• W2902997102 hasConcept C126322002 @default.
• W2902997102 hasConcept C164027704 @default.
• W2902997102 hasConcept C203014093 @default.
• W2902997102 hasConcept C2776914184 @default.
• W2902997102 hasConcept C2777714996 @default.

• next