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- W290301905 abstract "It is well known that during homology recognition and strand exchange the double stranded DNA (dsDNA) in DNA/RecA filaments is highly extended, but the functional role of the extension has been unclear. We present an analytical model that calculates the distribution of tension in the extended dsDNA during strand exchange. The model suggests that the binding of additional dsDNA base pairs to the DNA/RecA filament alters the tension in dsDNA that was already bound to the filament, resulting in a non-linear increase in the mechanical energy as a function of the number of bound base pairs. This collective mechanical response may promote homology stringency and underlie unexplained experimental results." @default.
- W290301905 created "2016-06-24" @default.
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- W290301905 date "2011-08-24" @default.
- W290301905 modified "2023-09-27" @default.
- W290301905 title "The Free Energy of dsDNA Basepair Triplets Bound to an ssDNA/RecA Filament May be a Non-Linear Function of the Number of Contiguous Bound Triplets" @default.
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