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- W2903048293 abstract "BACKGROUND:The relation of infection with acute coronary syndrome is ever contradictory.Many antibiotic trials have failed in treating acute coronary syndrome.We have planned to focus on the concept of molecular mimicry between infectious agents and human proteins leading to inflammation and thus clinical syndromes of atherosclerosis secondary to these inflammatory reactions mounted against human antigens.One such preserved hyman chaperone is HSP 60 from prokaryotic age which shares molecular mimicry with many viral and bacterial human shock proteins.When inflammation is mounted against these HSP, the released inflammatory cascade molecules cause atherosclerosis and/or plaque destabilization and acute coronary syndrome.AIM OF THE STUDY:To study the role of infection in activating inflammatory pathwasy in the pathogenesis of atherosclerosis and acute coronary syndromeOBEJECTIVE:1.To evaluate the role of bacterial and viral infection as a risk factor for STEMI through analysis of circulating levels of heat shock protein 60 in ACS patients on comparision with controls without ACS.2. To measure level of inflammation with high sensitivity c reactive eprotein and to evaluate its relation with HSP 60 and traditional risk factors of ACS.METHODOLOGY AND RESULTS :Ours is a case control study with 333 STEMI cases and 27 controls without ACS are studied.Traditional risk factors for ACS are assessed in both groups along with measurement of HSP 60 and hsCRP . HSP 60 and hsCP are considered to be indirect markers for infection and inflammation respectively.HSP60 is measured through spectrometric method analyzed through ELISA while hsCRP is read through automated COBAS analyzer. In cases further evaluation of features of echocardiography and coronary angiogram are studied.We found that circulating levels of hsCRP has statistical significance in cases(p<0.05) while levels of HSP 60 donot have significant p value but have ODDS ratio of 1.54 indicating the possibility of relation of infection with incidence of acute coronary syndrome and its outcome.On regression analysis of all traditional risk factors for ACS they donot seem to influence the levels of hsCRP and HSP 60 in cases and controls in a statistically significant manner." @default.
- W2903048293 created "2018-12-11" @default.
- W2903048293 creator A5038188603 @default.
- W2903048293 date "2015-04-01" @default.
- W2903048293 modified "2023-09-27" @default.
- W2903048293 title "Role of infection and inflammation in acute coronary syndrome" @default.
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