Matches in SemOpenAlex for { <https://semopenalex.org/work/W2903052893> ?p ?o ?g. }
- W2903052893 endingPage "473" @default.
- W2903052893 startingPage "473" @default.
- W2903052893 abstract "Neptunea arthritica cumingii (Nac) is a marine snail with high nutritional and commercial value; however, little is known about its active peptides. In this study, two multi-functional peptides, YSQLENEFDR (Tyr-Ser-Gln-Leu-Glu-Asn-Glu-Phe-Asp-Arg) and YIAEDAER (Tyr-Ile-Ala-Glu-Asp-Ala-Glu-Arg), were isolated and purified from meat and visceral mass extracts of Nac using a multi-bioassay-guided method and were characterized by using liquid chromatography-tandem mass spectrometry. Both peptides showed high antioxidant, angiotensin-converting enzyme (ACE)-inhibitory, and anti-diabetic activities, with half-maximal effective concentrations values less than 1 mM. Antioxidant and ACE-inhibitory activities were significantly higher for YSQLENEFDR than for YIAEDAER. In a zebrafish model, the two peptides exhibited strong scavenging ability for reactive oxygen species and effectively protected skin cells against oxidative damage without toxicity. Molecular docking simulation further predicted the interactions of the two peptides and ACE. Stability analysis study indicated that the two synthetic peptides maintained their activities under thermal stress and simulated gastrointestinal digestion conditions. The low molecular weight, high proportion of hydrophobic and negatively-charged amino acids, and specific C-terminal and N-terminal amino acids may contribute to the observed bio-activities of these two peptides with potential application for the prevention of chronic noncommunicable diseases." @default.
- W2903052893 created "2018-12-11" @default.
- W2903052893 creator A5029332492 @default.
- W2903052893 creator A5045258292 @default.
- W2903052893 creator A5058481549 @default.
- W2903052893 creator A5059639262 @default.
- W2903052893 creator A5063061958 @default.
- W2903052893 creator A5070828118 @default.
- W2903052893 creator A5079906436 @default.
- W2903052893 creator A5080610727 @default.
- W2903052893 date "2018-11-27" @default.
- W2903052893 modified "2023-09-25" @default.
- W2903052893 title "Two Novel Multi-Functional Peptides from Meat and Visceral Mass of Marine Snail Neptunea arthritica cumingii and Their Activities In Vitro and In Vivo" @default.
- W2903052893 cites W114346019 @default.
- W2903052893 cites W1537086174 @default.
- W2903052893 cites W159694880 @default.
- W2903052893 cites W1771007946 @default.
- W2903052893 cites W1967938006 @default.
- W2903052893 cites W1968078924 @default.
- W2903052893 cites W1968439728 @default.
- W2903052893 cites W1970918259 @default.
- W2903052893 cites W1972234685 @default.
- W2903052893 cites W1976106872 @default.
- W2903052893 cites W1985657511 @default.
- W2903052893 cites W1990481259 @default.
- W2903052893 cites W2004364256 @default.
- W2903052893 cites W2005087761 @default.
- W2903052893 cites W2017086067 @default.
- W2903052893 cites W2017772893 @default.
- W2903052893 cites W2023526026 @default.
- W2903052893 cites W2026564439 @default.
- W2903052893 cites W2030298136 @default.
- W2903052893 cites W2050328582 @default.
- W2903052893 cites W2051949556 @default.
- W2903052893 cites W2063881253 @default.
- W2903052893 cites W2065472233 @default.
- W2903052893 cites W2075404727 @default.
- W2903052893 cites W2084252683 @default.
- W2903052893 cites W2094697902 @default.
- W2903052893 cites W2119886550 @default.
- W2903052893 cites W2124225842 @default.
- W2903052893 cites W2126362895 @default.
- W2903052893 cites W2138846202 @default.
- W2903052893 cites W2148125367 @default.
- W2903052893 cites W2175228938 @default.
- W2903052893 cites W2265683731 @default.
- W2903052893 cites W2470430228 @default.
- W2903052893 cites W2503176961 @default.
- W2903052893 cites W2504896963 @default.
- W2903052893 cites W2513691179 @default.
- W2903052893 cites W2519978238 @default.
- W2903052893 cites W2593536665 @default.
- W2903052893 cites W2605302535 @default.
- W2903052893 cites W2613652104 @default.
- W2903052893 cites W2636028974 @default.
- W2903052893 cites W2750830408 @default.
- W2903052893 cites W2774705889 @default.
- W2903052893 cites W2794251447 @default.
- W2903052893 cites W2795149550 @default.
- W2903052893 cites W2796320859 @default.
- W2903052893 cites W2809855586 @default.
- W2903052893 cites W2889338605 @default.
- W2903052893 cites W314933065 @default.
- W2903052893 cites W819958236 @default.
- W2903052893 doi "https://doi.org/10.3390/md16120473" @default.
- W2903052893 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6315844" @default.
- W2903052893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30486436" @default.
- W2903052893 hasPublicationYear "2018" @default.
- W2903052893 type Work @default.
- W2903052893 sameAs 2903052893 @default.
- W2903052893 citedByCount "20" @default.
- W2903052893 countsByYear W29030528932019 @default.
- W2903052893 countsByYear W29030528932020 @default.
- W2903052893 countsByYear W29030528932021 @default.
- W2903052893 countsByYear W29030528932022 @default.
- W2903052893 countsByYear W29030528932023 @default.
- W2903052893 crossrefType "journal-article" @default.
- W2903052893 hasAuthorship W2903052893A5029332492 @default.
- W2903052893 hasAuthorship W2903052893A5045258292 @default.
- W2903052893 hasAuthorship W2903052893A5058481549 @default.
- W2903052893 hasAuthorship W2903052893A5059639262 @default.
- W2903052893 hasAuthorship W2903052893A5063061958 @default.
- W2903052893 hasAuthorship W2903052893A5070828118 @default.
- W2903052893 hasAuthorship W2903052893A5079906436 @default.
- W2903052893 hasAuthorship W2903052893A5080610727 @default.
- W2903052893 hasBestOaLocation W29030528931 @default.
- W2903052893 hasConcept C150903083 @default.
- W2903052893 hasConcept C162356407 @default.
- W2903052893 hasConcept C185592680 @default.
- W2903052893 hasConcept C202751555 @default.
- W2903052893 hasConcept C207001950 @default.
- W2903052893 hasConcept C2776151105 @default.
- W2903052893 hasConcept C2778004101 @default.
- W2903052893 hasConcept C2779281246 @default.
- W2903052893 hasConcept C2779815552 @default.
- W2903052893 hasConcept C31827203 @default.
- W2903052893 hasConcept C43617362 @default.
- W2903052893 hasConcept C48349386 @default.