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- W2903056501 startingPage "635" @default.
- W2903056501 abstract "One of the greatest challenges of cancer therapeutics nowadays is to find selective targets successfully. Prostate apoptosis response-4 (Par-4) is a selective tumor suppressor protein with an interesting therapeutic potential due to its specificity on inducing apoptosis in cancer cells. Par-4 activity and levels can be downregulated in several tumors and cancer cell types, indicating poor prognosis and treatment resistance. Efforts to increase Par-4 expression levels have been studied, including its use as a therapeutic protein by transfection with adenoviral vectors or plasmids. However, gene therapy is very complex and still presents many hurdles to be overcome. We decided to review molecules and drugs with the capacity to upregulate Par-4 and, thereby, be an alternative to reach this druggable target. In addition, Par-4 localization and function are reviewed in some cancers, clarifying how it can be used as a therapeutic target." @default.
- W2903056501 created "2018-12-11" @default.
- W2903056501 creator A5020031069 @default.
- W2903056501 creator A5021470342 @default.
- W2903056501 creator A5027716827 @default.
- W2903056501 creator A5037550979 @default.
- W2903056501 creator A5037984549 @default.
- W2903056501 creator A5040305214 @default.
- W2903056501 creator A5046086898 @default.
- W2903056501 creator A5079556443 @default.
- W2903056501 date "2019-03-29" @default.
- W2903056501 modified "2023-09-27" @default.
- W2903056501 title "Potential Therapeutic Agents Against Par-4 Target for Cancer Treatment: Where Are We Going?" @default.
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