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• W2903082371 abstract "To cope with the poor aqueous solubility of withaferin A, a broad-spectrum anti-cancer agent effective against therapy-resistant cancers, a polymer-drug conjugate was synthesized via a grafting-from-drug approach. Modification of withaferin A at the C27-OH with a chain transfer agent (CTA) for reversible addition-fragmentation chain transfer (RAFT) polymerization through a degradable ester bond was achieved with excellent control on the regioselectivity via a PFP-ester transesterification route. Subsequent RAFT polymerization with the hydrophilic N,N-dimethylacrylamide yielded a fully water-soluble conjugate. A decreased cytotoxicity in vitro indicated that withaferin A exists as a prodrug in the conjugate form and requires hydrolysis of the ester to regain its activity." @default.
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• W2903082371 date "2019-01-01" @default.
• W2903082371 modified "2023-10-12" @default.
• W2903082371 title "Water-soluble withaferin A polymer prodrugs via a drug-functionalized RAFT CTA approach" @default.
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• W2903082371 doi "https://doi.org/10.1016/j.eurpolymj.2018.11.043" @default.
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